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Example sentences for: cncs

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In fact, CNCS clusters may be a powerful source of data for inferring transcription factor specificity, as specific binding-site motifs are likely to be locally over-represented in CNCS clusters with demonstrable enhancer function.
As shown in Figure 8, the D. melanogaster genomic sequences corresponding to the CNCS cluster in the ap intron 4 drives reporter gene expression in the Drosophila embryo in a specific pattern that recapitulates native ap expression in the developing brain.
These data quantitatively describe the pattern of non-coding conservation shown in Figures 2and 4: CNCS lengths become shorter with increasing divergence but plateau to approximately the same length in the most distant comparisons.
The stability of this distribution at more extreme evolutionary distances is apparently insensitive to changes in the proportion of non-coding DNA that is conserved (compare D. willistoni and D. littoralis ). Shown for comparison is the distribution of CNCS lengths between D. melanogaster and D. virilis from [ 44], as well as a reanalysis of this data using the current methods.
Clustering of CNCSs and conservation of CNCS spacing are not expected under a mutational cold-spot hypothesis, and suggest that the spacer intervals between CNCSs, and therefore CNCSs themselves, are under functional constraint.