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Example sentences for: cncs

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Using CNCS clusters to identify enhancers represents the comparative genomic analogue of efforts to predict cis -regulatory sequences by exploiting the clustering of predicted transcription factor binding sites [ 70, 71].
Finally, successfully linking CNCS clusters with enhancer function will provide an alternative means of defining enhancer structure based on evolutionary rather than operational criteria.
The CNCS cluster carrying the ap brain enhancer was amplified from D. melanogaster (BAC) and D. virilis (P1) clones bearing the ap gene, respectively.
As yet, there has been no report of a general tendency for CNCSs to be clustered in mammalian genomes, although certain regions of the mammalian genome (such as the H19 region [ 69]) show a strong pattern of CNCS clustering.
For example, discrete enhancers that control embryonic expression of eve are contained within discrete CNCS clusters in the region 5' to eve (Figure 2).