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Example sentences for: cncs

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The CNCS cluster carrying the ap brain enhancer was amplified from D. melanogaster (BAC) and D. virilis (P1) clones bearing the ap gene, respectively.
Clustering of CNCSs and conservation of CNCS spacing are not expected under a mutational cold-spot hypothesis, and suggest that the spacer intervals between CNCSs, and therefore CNCSs themselves, are under functional constraint.
However, unlike binding-site clusters, CNCS clusters can be rapidly identified in the absence of any a priori information about transcription factor specificity, and may therefore provide a more general approach to genome-wide cis -regulatory prediction.
The correspondence of CNCS clusters and functional enhancers is observed in other regions of the Drosophila genome, such as the discrete muscle-specific enhancer in the fourth intron of
In fact, CNCS clusters may be a powerful source of data for inferring transcription factor specificity, as specific binding-site motifs are likely to be locally over-represented in CNCS clusters with demonstrable enhancer function.