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Example sentences for: cncs

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Clustering of CNCSs and conservation of CNCS spacing are not expected under a mutational cold-spot hypothesis, and suggest that the spacer intervals between CNCSs, and therefore CNCSs themselves, are under functional constraint.
However, unlike binding-site clusters, CNCS clusters can be rapidly identified in the absence of any a priori information about transcription factor specificity, and may therefore provide a more general approach to genome-wide cis -regulatory prediction.
To test the hypothesis that CNCS clusters can predict the location of cis -regulatory elements in the Drosophila genome, we carried out P -element-mediated reporter gene analysis of genomic sequences corresponding to a CNCS cluster in the fourth intron of ap . This CNCS cluster is apparent in pairwise comparisons between D. melanogaster and D. pseudoobscura as well as between
The differences observed in the distribution of CNCS lengths between the closely related species D. virilis and D. littoralis using the AVID-VISTA method reflect the fact that the D. virilis data were obtained from non-coding regions with known or suspected cis -regulatory function, whereas the data here represent a more random sampling of non-coding regions in the Drosophila genome.
Experiments to test the function of CNCS clusters 1, 2, and 3 in the ap region are currently underway.