Example sentences for: cml

How can you use “cml” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Gleevec has been shown to induce clinical, hematological and molecular remissions for CML patients [ 4 ] . It cross-reacts with two other important growth factor receptors containing tyrosine kinase domains, c-kit and PDGF receptors, that play important roles in growth and proliferation of a variety of cell types [ 5 ] . C-kit (also known as CD117) is frequently mutated in gastrointestinal stromal tumor (GIST), and the mutated c-kit shows higher tyrosine kinase activity.

  • To use physiologically relevant CML proteins in our in vitro experiments, we prepared CMLmin-BSA, characterized by glycation of approximately 30% of lysine residues [21].

  • This is within the known therapeutic ranges for patients with CML, since the plasma levels of Gleevec inducing hematologic and cytogenetic response in patients with CML were reported to be in the range of 0.1-3.

  • For example, in CML, a commonly found mutation is a C→T single nucleotide change that replaces threonine with isoleucine at position 315 (T315I) in the ABL kinase domain [9,10,11].

  • As a consequence, there have been additional dividends from the United States Federal Drug Administration approval of imatinib for treatment of BCR-ABL-positive CML.


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