Example sentences for: cml

How can you use “cml” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Subclones bearing this mutation could arise de novo during treatment . However, based upon analogous studies in CML, it is also possible that NSCLC subclones bearing this secondary mutation pre-exist within the primary tumor clone in individual patients, albeit at low frequency [23].

  • These results differ from those of acquired resistance mutation in CML [10], GIST [15,27], and HES [16].

  • Indeed, about three years after the recognition of imatinib resistance mutations in BCR-ABL-positive CML, new drugs are now in clinical trials that are potent inhibitors of imatinib-resistant BCR-ABL mutants [13,14].

  • Although imatinib inhibits different kinases in various diseases (BCR-ABL in CML, KIT or PDGFR-alpha in gastrointestinal stromal tumors [GISTs], and PDGFR-alpha in hypereosinophilic syndrome [HES]) (reviewed in [14]), some tumors that become refractory to treatment with imatinib appear to have analogous secondary mutations in the kinase-coding domain of the genes encoding these three enzymes.

  • Among the most abundant glucose-modified proteins detectable in the plasma of diabetic individuals are CML proteins [21], which are typically present at 1.6 to 2.3 μM concentrations in the plasma and urine of diabetic individuals [22,23].


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