Words similar to cmh
Example sentences for: cmh
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is expressed in skeletal muscle, with a less abundant ~7 kb transcript expressed in both skeletal and cardiac muscle [ 8 ] . Whereas tropomodulins or the Arp 2/3 complex cap the pointed end of actin filaments, the barbed end can be capped by CapZ, α, β, and γ adducins as well as gelsolin [ 9 10 11 ] . Control of thin filament length is critical for maintaining proper sarcomere function and length [ 12 ] . Inhibition of Tmod1's capping activity - either by using an antibody to its C-terminal end or by decreasing expression using an antisense Tmod1 transcript - results in elongated thin filaments and decreased cardiac contractility [ 13 14 ] . Tmod1 overexpression in rat cardiomyocytes causes shortening of the thin filaments and sarcomere disorganization, resulting in myofibril degeneration [ 14 ] . Likewise, mice overexpressing TMOD1 in the heart show disrupted sarcomere organization with shortened thin filaments, leading to myofibril degeneration and dilated cardiomyopathy [ 15 ] . Recently, Littlefield and colleagues showed that overexpression of GFP-Tmod1 in chick cardiac myocytes results in shortening of thin filaments; the authors proposed that excess Tmod1 decreases the affinity between actin monomers and pointed ends, leading to monomer dissociation and filament shortening [ 42 ] . Mutations in many proteins making up the cardiac sarcomere have been shown to cause cardiac hypertrophy [ 16 17 18 19 ] :mutations in the TPM1 gene, for example, cause type 3 familial hypertrophic cardiomyopathy (CMH3), and a transgenic mouse expressing a CMH3 mutation develops ventricular myocyte disarray and hypertrophy [ 20 ] . Mutations in myosin heavy chain 7 are estimated to account for 40-50% of the cases of hypertrophic cardiomyopathy [ 21 ] .
The lung was then suspended from a ring stand over a drip basin and the endotracheal tube was connected to a source of air equipped with a continuous positive airway pressure system set at a pressure of 30 cmH 2 O. The air pressure causing the fixative to weep from the pleural surface was maintained over 3 days, and a dry left lung with spongy texture was obtained.
4. positive response to inhaled NO, defined as a decrease in MPAP of at least 2 mmHg and an increase in PaO 2 (FiO 2 1.0, PEEP 10 cmH 2 O) of at least 40 mmHg after NO inhalation at an inspiratory concentration of 15 ppm.
Tidal volume was reduced to maintain peak airway pressures of less than 40 cmH 2 O. Respiratory rate was adjusted to maintain a pH of more than 7.30.
Baseline PEEP (PEEP baseline ) was set at 5 cmH 2 O and titrated at 2 cmH 2 O increments until the partial arterial oxygen tension (PaO 2 ) reached at least 300 mmHg, peak airway pressure was 45 cmH 2 O or greater, or MAP dropped by 20% or more from the baseline value.
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