Words similar to clpa

Example sentences for: clpa

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The number of examples in this category could be increased, and some have already been considered in the literature, for example the spurious discovery of a 'functional PDZ domain' in the molecular chaperone ClpA ([ 46], see refutation in [ 47]) or the finding of an ATPase domain and death effector domains in the apoptosis-associated protein FLASH ([ 48], see refutation in [ 49]).
However, such primordial di-protomeric AAA polypeptides would have to have been simpler than those present in NSF, ClpA and p97 and other AAA proteins of the current era, for the latter assemble into two-tiered hexameric assemblies, with the axis joining the two protomers in each polypeptide oriented perpendicular to the plane of the hexameric ring [ 14 ] . We cannot, at present, exclude an alternative model for midasin structure in which the hexameric AAA ring assembly is a dimeric two-layered structure formed by two midasin polypeptides arranged laterally with all six odd-numbered protomers in one layer and all six even-numbered protomers in the other.