Words similar to cisplatinum

Example sentences for: cisplatinum

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Studies have shown BRCA1 is upregulated in cells treated by DNA damaging agents such as cisplatinum [ 4 ] . BRCA1 has been shown to interact with DNA repair proteins such as Rad50 and Rad51, the tumor suppressor genes RB and BRCA2, transcriptional factors (RNA pol II, histone deacetylase complex, ctIP) as well as influence numerous cyclins and cyclin dependent kinases contributing to cell cycle regulation [ 5 6 7 8 9 10 11 12 ] . More recently, BRCA1 has been shown to influence apoptosis in a p53 independent manner [ 13 ] . This apoptotic response involved the c-jun kinase (JNK) pathway, though the details of this mechanism remain unclear [ 14 ] .
While the exact mechanism remains unclear, STS has been shown to initiate caspase driven apoptosis in a manner distinct from chemotherapeutic agents such as cisplatinum, etoposide, and tamoxifen, which directly cause DNA damage and tend to favor ERCC1 activation [ 37 38 ] .