Example sentences for: cisplatin

How can you use “cisplatin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Cisplatin was purchased from Sigma Chemicals (St.

  • Current study results suggests that Gleevec can potentiate the cisplatin effect on A549 lung cancer cells, and these findings provide important in vitro data for further testing the possibility of using Gleevec as adjuvant therapy for clinical lung cancer patients.

  • Synergistic effect of Gleevec and cisplatin on A549 cells

  • In response to DNA damage induced by ionizing radiation or chemical agents such as cisplatin, ATM kinase is activated and phosphorylates a number of downstream regulatory proteins important for cell cycle arrest, growth control, apoptosis and DNA repair [ 25 26 27 28 ] . AT patients are known to be predisposed to a variety of cancers, and the fibroblasts of AT patients are hypersensitive to ionizing radiation [ 29 ] . Although many reports showed the association of ATM mutation with risk of a number of different human malignancies, including prostate cancer, breast cancer, ovarian cancer, B-cell chronic lymphocytic leukemia and mantle cell lymphoma, the underlying molecular mechanism by which ATM gene causes these changes are not well understood [ 30 31 32 33 34 35 ] . There is so far no study showing the association of ATM gene with any solid tumor.

  • This synergistic effect of Gleevec and cisplatin on A549 lung cancer cells were not seen for human 293 kidney cells (Figure 5).


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