Words similar to cisplatin

Example sentences for: cisplatin

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The concentration of Gleevec to inhibit 50% cell growth (IC50) was estimated to be around 2-3 μM (Figure 1), whereas the IC50 of cisplatin on A549 cells was estimated to be 64-70 μM (Figure 2).
Epigenetic gene silencing of the MGMT confers enhanced sensitivity to alkylating agents in cancer [ 24 25 ] . Lack of methylation, on the other hand, associates with high-risk of death [ 25 26 ] . It has been suggested that the high-levels of MGMT proteins contribute to a drug-resistant phenotype [ 27 ] . More than 90% of newly diagnosed GCTs and 70-80% of patients who present metastatic disease are cured with cisplatin-based chemotherapy [ 28 ] . However, 20-30% of the patients with metastatic disease exhibit resistance to the cisplatin curative regimen leading to high mortality in this group.
Combination of Gleevec and cisplatin synergistically inhibited the growth of A549 cells (Figure 4).
Cisplatin causes two types of DNA damage, DNA adducts and inter-stranded cross-linking, resulting in activation of apoptosis pathway in the target tumor cells [ 13 14 ] . Our results suggest that inhibition of tyrosine kinase activity of the potential targets by Gleevec appear to potentiate the effect of cisplatin in DNA-damage induced apoptosis in A549 cells.
Synergistic effect of Gleevec and cisplatin on A549 cells