Words similar to circularized

Example sentences for: circularized

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ERCA is capable of 10 12-fold signal amplification [ 6 ] . In order to investigate the efficiency of the ERCA step, OCP was circularized by ligation on a synthetic oligonucleotide target, and gel-purified to remove any linear DNA.
Exponential amplification of circularized OCP (see Figure 2) was accomplished using generic primers P1 and P2, along with allele specific primer(s).
Similarly, OCP ligation/ERCA can be used to accurately genotype PCR products in a biallelic format, where the probes for both alleles are present in a single reaction [ 3 ] . The OCP ligation/ERCA method is based on ligation dependent circularization of allele specific DNA probes followed by exponential rolling circle amplification of the circularized probes [ 4 5 ] . ERCA probes have also been variously described as 'padlock probes' [ 6 7 ] or 'circularizable probes' [ 4 ] . Although OCP ligation/ERCA can be used to genotype PCR products, it also provides a means for directly genotyping genomic DNA without requiring an initial amplification of the genomic DNA locus.
The reaction was heated to 95°C for 10 seconds, and cooled to 63-68°C for 5-20 minutes, during which time OCP annealed to genomic target and was circularized by ligase.
In reactions where the OCP matches the SNP, an estimated 100-30,000 OCPs are circularized by ligation depending on the amount of input DNA target.