Words similar to chromatids
Example sentences for: chromatids
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The frequencies of MII oocytes displaying premature centromere separation (PCS), single chromatids (SC), premature anaphase (PA) were also calculated relative to the total number of MII oocytes analyzed.
There is specific labelling of both chromatids of both homologues of rat chromosome (RNO) 6 (Fig.
This indicates that about 95% of those rec12-Y98F mutant cells that produced diploid spores must have successfully completed the reductional segregation of chromosomes (MI) and failed to properly segregate sister chromatids during the equational division (MII).
During this transition, tightly-regulated post-translational phosphorylation-dephosphorylation events and proteasome-mediated proteolytic reactions regulate the activation and inactivation of signal transduction pathways that control chromatin condensation, nuclear membrane dissolution, microtubule nucleation, and formation of a haploid oocyte [ 8 9 10 ] . Several kinases that exert major roles during OM include maturation promoting factor (MPF) [ 9 11 ] , mitogen-activated protein kinases (MAPKs) [ 12 13 ] , and the product of the c-mos protooncogene Mos kinase [ 14 15 ] . Also, during OM oocytes undergo two highly-regulated metaphase-anaphase transitions (MAT) in which homologous chromosomes are equally and randomly segregated to an oocyte and first polar body and a subsequent division in which equational division of sister chromatids results in a haploid oocyte and a second polar body.
The origin of single, unpaired chromatids in MII oocytes has been proposed to result from premature separation of sister chromatids prior to anaphase I [ 56 57 ] . The possibility exists that both SC and aneuploidy may have originated from PCS of homologues and sister chromatids during the MAT of meiosis I. Upon removal of MG-132 from the culture media during meiosis I and the subsequent resumption of OM and proteasomal activity, faulty kinetochore-microtubule attachment accompanied by degradation of cohesion proteins could conceivably lead to PCS of homologues and sister chromatids.
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