Words similar to chrna
Example sentences for: chrna
How can you use “chrna” in a sentence? Here are some example sentences to help you improve your vocabulary:
Alternatively, this site, which contains a recent human-specific segmental duplication of the CHRNA7 locus, may be a preferential site of breakage, which allowed the pericentric inversion to occur.
We were able to discern two major duplicons from this analysis: one segment derived from the CHRNA7 locus in 15q13.
3 and the fact the CHRNA7 duplication appeared polymorphic in the human population [ 17 ] . This hypothesis deserved consideration in this study, as the site of duplication of the CHRNA7 locus in the human genome may correspond to the pericentric inversion breakpoint, and the high sequence homology noted between the donor and duplicated CHRNA7 loci does not establish the human-specificity of the CHRNA7 duplication, as gene conversion may also maintain high sequence homology of duplicated segments [ 26 27 ] . Thus, we tested the chimpanzee genome by Southern genomic analysis for the presence of the CHRNA7 duplication which revealed this duplication is most likely human-specific and therefore did not contribute to the pericentric inversion in chimpanzee (Figure 5).
The CHRNA7 duplication involves at least 125 kb of material (indicated in Figure 4), however because of the fragmented nature of the assembly in this region at this time, that number could increase with future versions of the human genome assembly.
Upon hybridization of this probe to a panel of human, pygmy chimpanzee, common chimpanzee and gorilla genomic DNAs, two bands were observed in the human sample and a single band was noted in all great ape species, providing further evidence that the CHRNA7 duplication was specific to humans and was not present at the time of the pericentric inversion event in the chimpanzee genome.
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