Words similar to chrna
Example sentences for: chrna
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In addition, FISH results with probe RP11-30N16, which contains the intact donor CHRNA7 locus, did not produce dual FISH signals on PTR XVp and XVq, further demonstrating this sequence is not involved in the evolutionary rearrangement.
Finally, the association of the dual FISH signal with clones that did not contain the CHRNA7 duplication (RP11-422F16) indicates the split signal is caused by a duplicated sequence within the 600 kb interval other than the CHRNA7 -related sequence.
Although the CHRNA7 duplication had, on the basis of sequence identity, previously been postulated to be human-specific, the location of this duplicon within the 600 kb interval associated with the pericentric inversion in chimpanzee necessitated determination of the copy number of CHRNA7 within the chimpanzee genome [ 17 ] . First, chimpanzee BAC library hybridizations (8.
The CHRNA7 duplication involves at least 125 kb of material (indicated in Figure 4), however because of the fragmented nature of the assembly in this region at this time, that number could increase with future versions of the human genome assembly.
Probe CHRNA7 - Pst I was designed by identifying an approximately 100 bp RFLP between the CHRNA7 -related sequence within accessions AC010799 (RP11-40J8) and AC111169 (RP11-20D7), using the web-based restriction mapping program Webcutter 2.0 [ 36 ] . Once a polymorphism distinguishing the two copies of CHRNA7 in Homo sapiens had been identified, probe CHRNA7 - Pst I was PCR amplified from BAC RP11-40J8 DNA using primers CHRNA7 .probe2.
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