Words similar to chrna
Example sentences for: chrna
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3 and the fact the CHRNA7 duplication appeared polymorphic in the human population [ 17 ] . This hypothesis deserved consideration in this study, as the site of duplication of the CHRNA7 locus in the human genome may correspond to the pericentric inversion breakpoint, and the high sequence homology noted between the donor and duplicated CHRNA7 loci does not establish the human-specificity of the CHRNA7 duplication, as gene conversion may also maintain high sequence homology of duplicated segments [ 26 27 ] . Thus, we tested the chimpanzee genome by Southern genomic analysis for the presence of the CHRNA7 duplication which revealed this duplication is most likely human-specific and therefore did not contribute to the pericentric inversion in chimpanzee (Figure 5).
apoe gene, who are asymptomatic, but at risk for Alzheimer's disease have been shown to have a specific deficit in orienting of attention that is in the same direction as the Alzheimer's patients [ 28 ] . Other studies using endophenotypic measures of attention have linked variation in the chrna7 gene with sensorimotor gating performance [ 29 ] and variation in the drd4 gene with attention deficits [ 30 ] . However, the tasks used in these studies have not generally involved either the orienting network alone, or the task involves an undefined combination of different networks.
To determine the evolutionary age of the CHRNA7 duplication with respect to the human/chimpanzee divergence, we performed a genomic Southern blot using DNA extracted with the PureGene DNA isolation kit (Gentra Systems, Minneapolis, MN).
Upon hybridization of this probe to a panel of human, pygmy chimpanzee, common chimpanzee and gorilla genomic DNAs, two bands were observed in the human sample and a single band was noted in all great ape species, providing further evidence that the CHRNA7 duplication was specific to humans and was not present at the time of the pericentric inversion event in the chimpanzee genome.
No evidence of CHRNA7 was found either by sequence-similarity searches or through sequence-tagged site (STS)-content hybridization mapping (data not shown).
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