Words similar to chondrocyte

Example sentences for: chondrocyte

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Bmp-2 signaling has a positive effect on chondrocyte proliferation [ 29 ] , and can induce Indian hedgehog (Ihh) expression in responsive cells [ 30 ] . We find Ihh mRNA elevated in Hoxc-8 transgenic chondrocytes (see Figure 8).
Ihh can induce Bmp expression in proliferating cells, further increasing positive effects on chondrocyte proliferation [ 31 ] . At the same time, Ihh decreases the rate of progression to hypertrophy [ 32 33 ] , again consistent with an accumulation of proliferating cells in our transgenic animals.
To assess chondrocyte proliferation in Hoxc-8 transgenic mice, we performed in vivo BrdU labeling experiments.
Their studies showed that chondrocyte death was most highly correlated with the degree of joint inflammation present 14 days after arthritis induction.
To examine this function in more detail, we employed a culture system that facilitates chondrocyte maturation and cartilage formation, and closely recapitulates the in vivo situation [ 11 ] . The micromass system has been used extensively for studies of cartilage formation from limb mesenchyme [ 10 11 12 13 ] and also for culture of chondrocytes in high density [ 14 ] . Here, we have adapted the system to neonatal mouse rib chondrocytes, to study the role of Hoxc-8 in chondrocyte maturation.