Words similar to chondrocyte
Example sentences for: chondrocyte
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The observed suppression of its expression in chondrocytes by IL-1β (Table 2, panel B) is consistent with a previous report in osteoblastic cells [ 44] and suggests that IL-1β may enhance cartilage degradation by blocking an essential autocrine signal for chondrocyte maturation and function.
Along with confirming changes in gene expression already known to be associated with IL-1β stimulation, chondrocyte biology, and MMP gene regulation, this microarray identified several other induced and repressed genes whose roles in chondrocyte biology are yet to be defined.
The cells in the center of the anlagen, which are initially immature, undergo an ordered differentiation program [ 2 ] (also called chondrocyte maturation [ 3 ] ): the chondrocytes proliferate, become pre-hypertrophic, and then undergo hypertrophy and matrix calcification.
Similar results were reported by other authors [ 15 16 17 ] . These results demonstrate that the cultured rib chondrocytes behaved in a similar manner as chondrocytes in vivo . Taken together, primary rib chondrocytes from mouse neonates grown in micromass culture display cellular differentiation, proliferation, maturation and hypertrophy, recapitulating the chondrocyte maturation program in vivo . These results establish the utility of this in vitro system to investigate the role of Hox genes and other transcription factors in endochondral ossification.
To examine this function in more detail, we employed a culture system that facilitates chondrocyte maturation and cartilage formation, and closely recapitulates the in vivo situation [ 11 ] . The micromass system has been used extensively for studies of cartilage formation from limb mesenchyme [ 10 11 12 13 ] and also for culture of chondrocytes in high density [ 14 ] . Here, we have adapted the system to neonatal mouse rib chondrocytes, to study the role of Hoxc-8 in chondrocyte maturation.
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