Words similar to chk

Example sentences for: chk

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In fission yeast, the checkpoint rad +genes ( hus1 +, rad1 +, rad3 +, rad9 +, rad17 +and rad26 +) and chk1 +manage the sensing and transducing operations of the DNA damage checkpoint [ 1 16 ] . Current data suggest that the Rad26/Rad3-kinase complex initially senses DNA damage by an unknown mechanism [ 17 ] . This response leads to an increase in the kinase activity of the complex [ 18 ] , which phosphorylates and activates the transducing protein kinase, Chk1 [ 19 ] . Finally, Chk1 delays mitotic entry by targeting Cdc25 and Wee1, regulators of cyclin-dependent kinase activity [ 20 21 22 ] .
12A), the increased expression of Chk1, Chk2, and E2F1 best discriminates control from SN50-treated explants.
While phosphorylation of serines 15 and 20 of p53 are clearly dependent on the ATM and chk2 protein kinases [ 10, 11, 12, 13, 14], the kinases responsible for phosphorylation of the remaining serine residues in vivo is not clear.
In addition, ATM phosphorylates and activates chk2 kinase [ 12].
Viewing the most defining proteins with altered expression, it is clearly reflective of increased apoptosis (increased Chk1, Caspase 6, E2F1), decreased cell proliferation and branching (decreased GR), and, interestingly, increased expression of diverse signal transduction pathways (Ras/Raf/ERK, JNK) to compensate for the proapoptotic signal.