Words similar to chimera
Example sentences for: chimera
How can you use “chimera” in a sentence? Here are some example sentences to help you improve your vocabulary:
In addition, we determined if tyrosine phosphorylation of endogenous FAK and endogenous Cas was affected by the presence of the chimera.
Indeed, phosphorylated endogenous Cas is localized to FAK and the focal adhesions via its SH3 domain and/or its Src binding domain in its distal C-terminus, both were excluded from our chimera, suggesting that proper localization of the tyrosine phosphorylated substrate domain may be required for Cas activity [ 30 45 ] .
Tyrosine phosphorylation of the substrate domain leads to the recruitment of other downstream adaptors such as crk and nck, as well as other downstream effectors possessing SH2 domains, and signaling events attributed to this domain include activation of the JNK MAPK pathway and control of adhesion and migration of cells [ 6 10 16 38 44 ] . We constructed a chimera between a kinase that phosphorylates Cas in vivo and the substrate domain of Cas, in order to determine events regulated by this domain.
If an individual were a chimera comprising full-sibling tissues (identical across approximately half of their genomes), there might be conflict between the two nonidentical cell lineages, as there is between the tissues of a mother mammal and her fetus (also identical across half of their genomes) during pregnancy (Haig 2002).
Transient expression of the Src*/Cas(SD) in Cos-7 cells followed by analysis of total cell lysates using anti-phosphotyrosine antibodies demonstrated that while the attenuated Src kinase domain alone did not increase total cellular tyrosine phosphorylated proteins as expected, expression of the Src*/Cas(SD) fusion resulted in tyrosine phosphorylation of a protein of the expected size of the chimera, as well as other proteins (Fig.
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