Words similar to chimera

Example sentences for: chimera

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Tyrosine phosphorylation of the substrate domain leads to the recruitment of other downstream adaptors such as crk and nck, as well as other downstream effectors possessing SH2 domains, and signaling events attributed to this domain include activation of the JNK MAPK pathway and control of adhesion and migration of cells [ 6 10 16 38 44 ] . We constructed a chimera between a kinase that phosphorylates Cas in vivo and the substrate domain of Cas, in order to determine events regulated by this domain.
The JNK pathway is regulated by interaction of c- or v-crk with Cas via the substrate domain [ 38 ] . In determining which pathways are affected in our stable cell lines generated, we determined if JNK was activated in the v-crk transformed cells, and if the tyrosine phosphorylated Cas chimera was affecting this activation.
Figure 7bdemonstrates that there was no difference in tyrosine phosphorylation or association with tyrosine phosphorylated proteins of either FAK or endogenous Cas upon stable expression of the tyrosine phosphorylated Cas SD chimera.
Alignment selections in JEvTrace can be mapped to the Chimera structure viewer [ 49] using an earlier version of the SCF format available in JEvTrace.
To determine if the tyrosine-phosphorylated Cas SD chimera affected other signaling pathways, we tested whether the association between c-crk and C3G was affected in NIH3T3 cells expressing the chimera (Fig.