Words similar to chimera
Example sentences for: chimera
How can you use “chimera” in a sentence? Here are some example sentences to help you improve your vocabulary:
In contrast, the chimera containing the kinase inactive domain was not stably phosphorylated in cells.
Experiments used the chimeras expressed either via the pJ3H vector, or the HA-tagged chimera subcloned into the expression vector pMEXneo [ 48 ] . The oncogene v-crk and its mutants cloned into pMEXneo have been described [ 49 50 ] .
Indeed, phosphorylated endogenous Cas is localized to FAK and the focal adhesions via its SH3 domain and/or its Src binding domain in its distal C-terminus, both were excluded from our chimera, suggesting that proper localization of the tyrosine phosphorylated substrate domain may be required for Cas activity [ 30 45 ] .
The JNK pathway is regulated by interaction of c- or v-crk with Cas via the substrate domain [ 38 ] . In determining which pathways are affected in our stable cell lines generated, we determined if JNK was activated in the v-crk transformed cells, and if the tyrosine phosphorylated Cas chimera was affecting this activation.
Finally, we can theoretically target this tyrosine phosphorylated chimera to specific areas of the cell to determine which cellular localization will recover the activation of downstream Cas functions.