Words similar to chelating
Example sentences for: chelating
How can you use “chelating” in a sentence? Here are some example sentences to help you improve your vocabulary:
To alleviate iron loading, chelating agents such as desferrioxamine (Desferal ®) and, most recently, deferiprone (Ferriprox ®) are available.
To disrupt the actin filaments of the cytoskeleton, the cell monolayer was treated with 25 nM cytochalasin D for 20 min at 37°C; TGFβ 1 was then applied in the presence of 25 nM cytochalasin D. For chelating intracellular calcium, the cells were preincubated with 5 μM of 1,2-bis(2-aminophenoxy)ethane- N , N , N ', N '-tetraacetic acid, acetoxymethyl ester (BAPTA-AM) for 15 min.
However, dramatic reduction of copper in SOD1 by knocking out the copper chaperon for SOD1 (CCS), or by mutating the copper chelating residues, did not affect ALS progression in vivo [ 36 48 ] . Therefore, the role of copper-mediated oxidative damage remains unclear [ 49 50 ] .
The National Library of Medicine's computerized bibliographic database (Medline 1966 to December 1999) was searched using a combination of the following keywords: thalassemia, serum ferritin, urinary iron excretion, hepatic iron, liver, chelation therapy, iron chelation, iron chelating agents, desferal, desferrioxamine, deferoxamine, L1 oral chelate, deferiprone and 1,2-dimethyl-3-hydroxypyrid-4-one.
While no one method is superior for all clinical scenarios, until recently measurement of hepatic iron stores - through liver biopsy or magnetic susceptometry - has provided the most quantitative, specific and sensitive method for determining the body iron burden in patients with thalassemia major and was considered the reference method for comparison with other techniques [ 2 4 ] . In the future, the newer advanced magnetic-resonance techniques, which allow for the assessment of both liver and cardiac iron, might provide an even more accurate assessment of total body iron [ 5 ] . Measurement of the magnitude of iron loading is useful in evaluating the effectiveness of the chelating agent, calibrating patient-specific treatment, and, in clinical research, as a determinant of clinical outcome.
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