Words similar to checkpoint-induced
Example sentences for: checkpoint-induced
How can you use “checkpoint-induced” in a sentence? Here are some example sentences to help you improve your vocabulary:
A mutant allele, rad26.T12 , genetically separates these functions, since rad26.T12 cells can undergo checkpoint-induced cell cycle arrest but fail to recover and lose viability [ 13 40 ] . To determine if spots and speckles are associated with these different Rad26 functions, we tagged the C-terminus of Rad26.T12 with GFP using the same primers and method that we used to tag Rad26 (see Methods).
The checkpoint system in fission yeast also allows cells to recover from checkpoint-induced cell cycle arrest [ 9 39 40 ] . Together with the other Checkpoint Rad proteins, the Rad26/Rad3 complex controls this genetically defined pathway that likely regulates DNA repair activities.
These data suggest that both patterns of Rad26-GFP fluorescence (spots and speckles) occur as a result of DNA damage, as opposed to the checkpoint-induced G2/M cell cycle delay that follows Bleomycin treatment.
For instance, rad26.T12 cells undergo checkpoint-induced cell cycle arrest, but lose viability upon re-entry into the cell cycle [ 40 ] . The rad26.T12 mutation acts by reducing the stability and activity of the Rad26/Rad3 checkpoint complex [ 18 ] , suggesting that cell cycle arrest requires only a pulse of Rad26/Rad3 kinase activity while recovery may require more.
22 rad26-GFP cells (Figure 6), so they likely resulted from Bleomycin-induced DNA damage as opposed to checkpoint-induced cell cycle arrest.