Example sentences for: checkpoint

How can you use “checkpoint” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Abnormal chromosome segregation has been observed in mice lacking the Mad2 checkpoint protein [ 25 ] . The spindle checkpoint utilizes sensory proteins that detect kinetochore-microtubule tension and occupancy and transiently block anaphase until all of the chromosomes are properly attached to microtubules [ 16 26 27 ] . Although the mammalian spindle checkpoint appears to differ between mitosis and meiosis, the two meiotic divisions, and male and female germ cells [ 28 ] , anaphase subsequently follows stable kinetochore-microtubule attachments [ 17 29 ] in both vertebrate mitotic [ 30 ] and meiotic [ 31 ] cells.

  • Further study of these structures and their regulation could provide important new information about the early steps in DNA damage detection and the checkpoint pathway.

  • Similar to results obtained in a wild-type background, we observed that between 48% and 56% of checkpoint radΔ cells formed one or two bright, Rad26-GFP spots following Bleomycin treatment (Figures 5Cand 7).

  • The cdc25 +gene encodes a positive mitotic regulator [ 50 ] that is also a target of DNA damage checkpoint signaling [ 51 ] . At the restrictive temperature (37°C), the temperature-sensitive cdc25.

  • Cars usually can go just a short distance before reaching a checkpoint where they have to turn back.


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