Words similar to ceramide

Example sentences for: ceramide

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TNFα elevates ceramide in CLENDO cells, whereas sFasL elevates ceramide in primary luteal steroidogenic cells [ 26 ] . Ceramide treatment induces apoptosis in both cell types, suggesting that the sphingomyelin pathway may be a common mediator of cell death among distinct cell types within the CL.
The exact role and functional significance of ceramide production in response to TNFα in CLENDO cell apoptosis are not presently known.
The amount of ceramide generated by CLENDO cells in response to TNFα treatment (50 ng/ml) was determined in three independent sets of experiments via the diacyl glycerol kinase assay as described [ 26 40 ] . Each experiment contained an untreated control that was used for comparison with TNFα treated samples.
These experiments as well as future studies designed to identify the enzymatic pathway(s) and in which cellular compartment(s) ceramide is generated in luteal microvascular endothelial cells in response to TNFα treatment should help determine which, if any, of the acutely activated signal transduction pathways contribute to luteal endothelial cell apoptosis.
For Western blot analysis, CLENDO cells were treated with TNFα (50 ng/ml) or C2 ceramide for 0, 2, 5, 10, 30, or 60 min.