Example sentences for: ceramide

How can you use “ceramide” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Ceramide in the lipid extracts were labeled with [ 32P-ATP] and the resulting products resolved using thin layer chromatography.

  • In the present study we provide evidence that TNFα and a by-product of TNFα signaling, ceramide, both have the capacity to activate members of the MAPK family.

  • For Western blot analysis, CLENDO cells were treated with TNFα (50 ng/ml) or C2 ceramide for 0, 2, 5, 10, 30, or 60 min.

  • Substantial data support the notion that ceramide serves as an upstream signaling molecule in the activation of other signaling pathways such as the mitogen-activated protein kinase (MAPK) superfamily [ 33 ] . In the present study quantitative measures were performed on members of the MAPK superfamily using antibodies that recognize only the phosphorylated, and presumptively active, forms of ERK, JNK, and p38.

  • Sphingomyelin content and luteal cell membrane fluidity decrease during luteolysis in vivo [ 48 49 50 51 ] . Ceramide, a product of sphingomyelin hydrolysis, is a potent stress-activated second messenger and is well established as a functional component of death receptor-mediated apoptosis [ 52 53 54 ] . Upon treatment of CLENDO cells with TNFα, we observed a rapid and sustained increase in the production of ceramide, suggesting that the sphingomyelin pathway is present and active in these cells.


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