Words similar to ceramide

Example sentences for: ceramide

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Substantial data support the notion that ceramide serves as an upstream signaling molecule in the activation of other signaling pathways such as the mitogen-activated protein kinase (MAPK) superfamily [ 33 ] . In the present study quantitative measures were performed on members of the MAPK superfamily using antibodies that recognize only the phosphorylated, and presumptively active, forms of ERK, JNK, and p38.
TNFα elevates ceramide in CLENDO cells, whereas sFasL elevates ceramide in primary luteal steroidogenic cells [ 26 ] . Ceramide treatment induces apoptosis in both cell types, suggesting that the sphingomyelin pathway may be a common mediator of cell death among distinct cell types within the CL.
Interestingly it has been demonstrated that rapid production of ROS in endothelial cells exposed to TNFα is mediated by ceramide [ 32 ] . Ceramide is a central figure in the sphingomyelin pathway, which has also been linked to stress related signaling and apoptosis [ 33 34 ] . This report provides evidence that cytokines regulate the fate of CLENDO cells.
However, treatment with C2 ceramide did activate the JNK pathway similar to that observed with TNFα treatment (Fig.
Exogenous ceramide induced CLENDO cell oligonucleosomal DNA fragmentation and reduced cell viability in a manner consistent with TNFα treatment.