Words similar to ceramide

Example sentences for: ceramide

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These experiments as well as future studies designed to identify the enzymatic pathway(s) and in which cellular compartment(s) ceramide is generated in luteal microvascular endothelial cells in response to TNFα treatment should help determine which, if any, of the acutely activated signal transduction pathways contribute to luteal endothelial cell apoptosis.
In the present study we provide evidence that TNFα and a by-product of TNFα signaling, ceramide, both have the capacity to activate members of the MAPK family.
Sphingomyelin content and luteal cell membrane fluidity decrease during luteolysis in vivo [ 48 49 50 51 ] . Ceramide, a product of sphingomyelin hydrolysis, is a potent stress-activated second messenger and is well established as a functional component of death receptor-mediated apoptosis [ 52 53 54 ] . Upon treatment of CLENDO cells with TNFα, we observed a rapid and sustained increase in the production of ceramide, suggesting that the sphingomyelin pathway is present and active in these cells.
To confirm specificity of ceramide in triggering CLENDO cell death, cultures were treated with sphingosine-1-phosphate (S1P; 10 or 50 μM; BioMol; Plymouth Meeting, PA) for 48 h.
2α (1 μM; Sigma Chemical Company; St. Louis, MO) or C2 ceramide (50 μM; BioMol; Plymouth Meeting, PA) for 24, 48 and 72 h.