Words similar to ceramide
Example sentences for: ceramide
How can you use “ceramide” in a sentence? Here are some example sentences to help you improve your vocabulary:
Under these conditions apoptosis may result from the production of cytokines [ 1 ] , cell activation [ 2 3 4 ] , infective agents [ 5 ] and adverse responses to pharmaceuticals [ 6 7 ] . Depending on the agonist or eliciting milieu, apoptotic cell death is accompanied by the activation of various cell death pathways including caspases, ceramide, altered gene expression, mitochondrial dysfunction and consumption of ATP e.g., with DNA repair, that result in histone-associated DNA fragmentation [ 8 9 ] . Many of these cell death pathways are also associated with the secondary production of oxidants [ 10 ] which appears to contribute to the magnitude of cell death.
Furthermore, to determine if S1P attenuated ceramide- or TNFα-induced cell death, CLENDO cells were first pretreated with S1P for 30 min, followed by application of ceramide (50 μM) or TNFα (50 ng/ml).
These experiments as well as future studies designed to identify the enzymatic pathway(s) and in which cellular compartment(s) ceramide is generated in luteal microvascular endothelial cells in response to TNFα treatment should help determine which, if any, of the acutely activated signal transduction pathways contribute to luteal endothelial cell apoptosis.
Oligonucleosomal DNA fragmentation was used as a biochemical marker of endothelial cell apoptosis in which cells were untreated for 48 h, treated with TNFα (50 ng/ml) for 12, 24 or 48, or treated with C2 ceramide (50 μM) for 12 h.
Treatment with 50 μM C2 ceramide failed to activate the ERK and p38 MAPK pathways.
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