Words similar to cefaclor

Example sentences for: cefaclor

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In studies with cefoxitin, cefaclor, and cephalothin as substrate, the observed k cat values for the S224A and S224K mutants were 2- to 7-fold lower; however, the k cat values when using nitrocefin as substrate were slightly higher (< 2-fold).
The changes in molar absorptivities (Δε) used to quantitate products were (in M -1cm -1): nitrocefin, Δε 485 = 17,420; cephalothin, Δε 265 = -8,790; cefoxitin, Δε 265 = -7,000; cefaclor, Δε 280 = -6,410; imipenem, Δε 300 = -9,000; meropenem, Δε 293 = -7,600; biapenem, Δε 293 = -8,630; ampicillin, Δε 235 = -809; and penicillin G, Δε 235 = -936.
Wild-type L1 exhibited k cat values of 41 ± 1 s -1, 1.9 ± 0.1 s -1, 42 ± 1 s -1, and 82 ± 5 s -1for the cephalosporins, nitrocefin, cefoxitin, cefaclor, and cephalothin.
also reported stopped-flow fluorescence studies when using cefaclor and meropenem as substrates, and K S values for these substrates were reported to be 710 ± 180 and 272 ± 112 μM, respectively [ 40 ] . However in our hands, the rates of substrate hydrolysis were so fast when using wild-type L1 that we could not use substrate concentrations high enough to saturate the enzyme.
However when cefaclor was used as substrate, the I164A mutant exhibited a 3-fold decrease in K m and a 1.5-fold decrease in k cat (Table 3).