Words similar to cbp
Example sentences for: cbp
How can you use “cbp” in a sentence? Here are some example sentences to help you improve your vocabulary:
Thus the down-regulation of SNIP1 likely leads to the liberation of CBP/p300 and directly contributes to the well-known transcriptional modulator functions of Smad1 and Smad4.
The interaction of Tat with p300/CBP and P/CAF stimulates its ability to transactivate LTR-dependent transcription, while Tat-TAF II 250 or Tat-Tip60 interactions control the transcription of cellular genes.
The functional characterization of clone 19 (SNIP1) as a novel CBP/p300 interactor and repressor has been reported recently in the signaling pathways of TGF-β [ 25 ] . The functional characterization of clone 12 (SIP2) as a new member of the sorting nexin family member has also been reported [ 31 ] . Studies of the novel protein SIP3 will be reported separately (Paralkar et al, manuscript in preparation).
Repression of RA responsive gene expression was believed due to the inability of this RAR to interact with CBP via its shortened carboxyl terminus [ 5 ] . By the same token this mutant receptor did not affect RA inhibition of AP-1 activity, presumably due to its inability to compete for CBP [ 11 ] . We observed decreased AP-1 activity in transient transfections using the RAR403 mutant likely due to decreased EGFR expression.
The transcriptional regulatory activities of Smad1 in the nucleus are associated with its ability to directly bind to DNA [ 12 ] , its interaction with other DNA-binding transcription factors, such as OAZ, SIP1 and Hoxc-8 [ 13 14 15 ] , and also its interaction with the master transcriptional co-activator CBP/p300 [ 16 ] . Smad4 is an essential functional partner in Smad-regulated transcription and also interacts with CBP/p300 via a domain within the central linker region named as SAD (Smad Activation Domain) [ 13 ] . Since CBP/p300 has intrinsic histone acetyltransferase (HAT) activity and participates in chromatin remodeling, the recruitment of CBP/p300 into the DNA-binding complexes of Smad1 and Smad4 is likely a critical step in Smad-regulated gene activation.
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