Words similar to catalytic
Example sentences for: catalytic
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One of these corresponds to the catalytic, metal-coordinating domain, containing the DbDGD motif, in the β' subunit (residues: 626-750 of pdb id:1iw7 chain D), whereas the other one corresponds to the conserved core domain of the β subunit (residues:673-994 of pdb id: 1iw7 chain C).
In many proteins, the catalytic peptidase domain is fused to domains such as SH3, LysM, and choline-binding domains [ 51, 52] (Figure 3).
A version of the CYTH domain, which is fused to the catalytic domain of nucleotide kinases, lacks the predicted catalytic residues, and probably function as an allosteric regulatory domain.
While the catalytic core is generally necessary and sufficient for the phosphohydrolase activity of PPP enzymes, the residues outside the core play critical roles in binding accessory proteins or small molecules that modulate the catalytic activity [ 25 26 27 28 29 ] . Specifically in the PP5 class, the N-terminus has been shown to contain three TPR motifs [ 5 6 7 8 ] , the three-dimensional structure of which is now also available [ 8 ] . Interestingly, the N-terminal sequence of PfPP5 was the longest of all, and seemed to contain four TPR motifs instead of three (Fig.
In an earlier investigation on the role of the p51 subunit of HIV-1 RT, we demonstrated that decrease in size of its β7-β8 loop impairs the catalytic function of the heterodimer [ 15 ] . In the present studies, we demonstrate that maintaining the wild type size of this loop in the p51 subunit is critical for dimerization of the enzyme and its catalytic activity.
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