Example sentences for: cascade

How can you use “cascade” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Two immunoglobulins which are particularly important in the cell adhesion cascade are Intercellular Adhesion Molecule-1 (ICAM-1) or CD54 and Vascular Cell Adhesion Molecule-1 (VCAM-1).

  • It has been established that, to achieve its maximal transcriptional activity, STAT1 must be phosphorylated on both Tyr701 and Ser727 [ 32 ] . Phosphorylation of STAT1 on Ser727 occurs in response to LPS, UV irradiation and other agents that activate the p38MAPK pathway [ 33 ] . As phorbol esters can also stimulate the MAPK cascade through activation of PKC [ 34 ] , it is tempting to speculate that combined treatment of cells with PMA and IFNg could increase the pool of STAT1 molecules phosphorylated on both Tyr701 and Ser727.

  • The two major groups of proteinases involved in extracellular matrix degradation - serine proteinases and metalloproteinases - have been grouped by literature profiling (Figure 6b: urokinase plasminogen activation cascade (UPA, PLAUR, SERPIN) and matrix metalloproteinases (MMP14, MMP10, MMP1)).

  • The characteristics of the inflammatory response in sepsis suggest that successful treatment requires a clinically useful marker which can indicate the severity of illness and which is expressed early enough in the sepsis cascade to allow therapeutic interventions to be initiated in a timely manner [ 4].

  • The fluorescent intensity of the oxidized OxyBURST in the lysosomes was then quantified using the staining of Cascade Blue-conjugated dextran as a mask, as described previously [ 8 ] . The average fluorescence intensity (gray level/pixel area) in the mask region was then calculated and represents the relative oxidative activity in lysosomes.


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