Example sentences for: cascade

How can you use “cascade” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • These protein complexes can consist of signaling proteins involved in several parallel inputs or several consecutive steps in a signaling cascade [ 35].

  • MMP-9 is secreted in an inactive zymogen form and can be activated in vitro by the plasmin cascade and through other MMPs [ 30, 31, 32, 33].

  • Skin antigen-presenting cells (Langerhans cells) appear to play an important role in the initiating events that lead to the cytokine cascade that results in keratinocyte proliferation and development of psoriatic lesions [ 16 17 18 ] . Effective therapeutic approaches to psoriasis treatment, such as psoralen UV-A therapy (PUVA), which result in depletion of APCs in the skin [ 19 20 ] , and UV-B [ 21 ] , lead to one of the most sustained improvement in psoriasis.

  • IL-6 receptor binding activates JAK1 as well as JAK2, which in turn phosphorylates STAT3 [ 14 ] . This in fact has been shown to be the case for v-src-transformed fibroblasts [ 34 ] . Another hypothesis is that STAT3 activation in NRP-154 cells is not dependent upon a signaling cascade, but is constitutive, possibly due to a mutation not unlike that contained within the cSTAT3 plasmid generated by Bromberg, et al.

  • The unstable configuration that results makes one vulnerable to a cascade of change.


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