Example sentences for: carboxyterminus

How can you use “carboxyterminus” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This effect requires the aminoterminus of DFz2, implying a requirement for binding Wg to the Fz CRD, but not the carboxyterminus, suggesting that the signal may be, in part, transmitted through an interaction of Wg-Frizzled complex with another protein.

  • In this experiment, a Wg plasmid activated the luciferase reporter only 12-fold above the vector control; wild-type DFz2 plasmid alone stimulated luciferase levels 7-fold, but neither deletion mutant of DFz2 had any effect, consistent with an earlier report that DFz2 with a truncated carboxyterminus fails to induce the expression of Xnr/Siamois [ 21 ] . However, DFz2ΔC stimulated signaling over 700-fold when delivered in concert with Wg, a synergistic effect nearly as strong as observed with wild type DFz2 (nearly 1700-fold in this experiment).

  • Therefore, the interaction between DFz2 and Dsh does not depend solely on the carboxyterminus of DFz2.

  • DFz2 reportedly binds to Wg through its CRD domain [ 6 ] , but it is not known which proteins interact with the carboxyterminus or with cytoplasmic loops in the 7-TM region of DFz2 to transduce the signal to the cytoplasmic signaling component Dsh.

  • If the carboxyterminus of LRP6 can interact with Axin independently of DFz2 and Dsh, it might reduce the cytoplasmic level of Axin and help stabilize β-catenin.


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