Example sentences for: cap-independent

How can you use “cap-independent” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Thus the full-length human p27 Kip15'-UTR is able to mediate cap-independent translation in a manner similar to that previously shown for the 217 nucleotide sequence of the mouse 5'-UTR [ 28 ] .

  • It was recently demonstrated that elements within a 217 nucleotide sequence from the 5'-UTR of the mouse p27 Kip1mRNA is able to mediate cap-independent translation of a reporter gene in NIH3T3 and D6P2T cells [ 28 ] . There is a high level of sequence homology between the mouse and human 5'-UTRs and the major transcriptional start site is also conserved [ 29 ] . Therefore it is likely the 5'-UTR of the human p27 Kip1message is also able to mediate cap-independent translation initiation.

  • This property is shared by the highly homologous mouse p27 Kip15'-UTR [ 28 ] . Coexpression of 4EBP-1-5A with the bicistronic construct containing the p27 Kip15'-UTR leads to an approximately two-fold increase in cap-independent expression.

  • One possibility is that the p27 Kip1mRNA is translated through a cap-independent mechanism that does not require eIF4E.

  • Part of this can be explained by the fact that the p27 Kip15'-UTR is able to promote cap-independent translation.


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