Example sentences for: cap-independent

How can you use “cap-independent” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • It has been shown that expression of p27 Kip1is controlled at the translational level [ 3 26 29 ] and that the p27 Kip15'- UTR is able to mediate enhanced translation rates [ 31 ] . In addition, it was recently reported that the p27 Kip15'- UTR has an internal ribosome entry site that allows cap-independent initiation of translation [ 30 ] . However, none of these reports have utilized the full 5'- UTR that results from transcription initiation at the major start site.

  • Part of this can be explained by the fact that the p27 Kip15'-UTR is able to promote cap-independent translation.

  • This property is shared by the highly homologous mouse p27 Kip15'-UTR [ 28 ] . Coexpression of 4EBP-1-5A with the bicistronic construct containing the p27 Kip15'-UTR leads to an approximately two-fold increase in cap-independent expression.

  • Expression of constitutively active 4EBP-1-5A enhances cap-independent translation through the p27 Kip15'-UTR

  • One possibility is that the p27 Kip1mRNA is translated through a cap-independent mechanism that does not require eIF4E.


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