Example sentences for: cancerization

How can you use “cancerization” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The concept of "field cancerization" hypothesizes that regions of the mucosal epithelium, although normal in appearance, are "preconditioned" by chronic exposure to carcinogenic agents, thus priming them for the subsequent development of invasive lesions [ 2 ] .

  • Entire lobules and large ducts of normal breast tissue can be derived from a single progenitor cell [ 47 ] , and LOH at various chromosomal locations is frequently detectable in morphologically normal lobules adjacent to breast tumors [ 48 ] . Lung tumors and head and neck tumors that develop in a localized region also often have a common clonal origin [ 3 4 49 ] . The high frequency of M6P/IGF2R loss of heterozygosity observed in the head and neck tumors in this study suggests that the phenomenon of "field cancerization", first described by Slaughter and his colleagues [ 2 ] in 1953, may in part result from the clonal proliferation of mucosal epithelial cells with M6P/IGF2R allelic loss.


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