Words similar to canalicular
Example sentences for: canalicular
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To date, the genes that have been shown to be responsive to regulation by FXR encode proteins involved in the biosynthesis and transport of bile acids [ 13 ] . Bile acids have been shown to modulate a variety of other cellular functions, such as secretion of lipoproteins from hepatocytes [ 14 15 ] and translocation of bile acid transporters to the hepatocyte canalicular membrane [ 16 ] . In McNtcp cells, which are liver-derived cells engineered to transport bile acids actively [ 17 ] , taurine-conjugated bile acids induce the formation of intracellular vesicles that resembles structures observed in cholestatic liver cells without apparent cellular cytotoxicity [ 1 18 ] . In contrast, glycine-conjugated bile acids promote apoptosis in these cells [ 19 ] . Thus, different classes of conjugated bile acids stimulate distinctive responses in McNtcp cells.
ATP-dependent transporters on the canalicular membranes of hepatocytes mediate the secretion of bile acids into bile [ 9 ] .
E15 SMG (mostly Canalicular Stage) primordia were cultured using a modified Trowell method as previously described [ 13 ] . The medium consisted of BGJb (Life Technologies, Rockville, MD) supplemented with 0.5 mg ascorbic acid/ml and 50 units penicillin/streptomycin (Life Technologies), pH 7.2, and replicate cultures were changed every other day.
Epithelial cell apoptosis begins with the onset of lumen formation in the Canalicular Stage.
Of these, the sodium/bile acid co-transporting polypeptide (ntcp) is considered to be quantitatively the most important transporter of conjugated bile acids in these cells [ 7 8 ] . The transport of bile acids from the basolateral to the canalicular membrane of liver cells is a poorly understood process.
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