Words similar to canalicular
Example sentences for: canalicular
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To date, the genes that have been shown to be responsive to regulation by FXR encode proteins involved in the biosynthesis and transport of bile acids [ 13 ] . Bile acids have been shown to modulate a variety of other cellular functions, such as secretion of lipoproteins from hepatocytes [ 14 15 ] and translocation of bile acid transporters to the hepatocyte canalicular membrane [ 16 ] . In McNtcp cells, which are liver-derived cells engineered to transport bile acids actively [ 17 ] , taurine-conjugated bile acids induce the formation of intracellular vesicles that resembles structures observed in cholestatic liver cells without apparent cellular cytotoxicity [ 1 18 ] . In contrast, glycine-conjugated bile acids promote apoptosis in these cells [ 19 ] . Thus, different classes of conjugated bile acids stimulate distinctive responses in McNtcp cells.
Of these, the sodium/bile acid co-transporting polypeptide (ntcp) is considered to be quantitatively the most important transporter of conjugated bile acids in these cells [ 7 8 ] . The transport of bile acids from the basolateral to the canalicular membrane of liver cells is a poorly understood process.
E15 SMG (mostly Canalicular Stage) primordia were cultured using a modified Trowell method as previously described [ 13 ] . The medium consisted of BGJb (Life Technologies, Rockville, MD) supplemented with 0.5 mg ascorbic acid/ml and 50 units penicillin/streptomycin (Life Technologies), pH 7.2, and replicate cultures were changed every other day.
24 agrees with a previous study showing that TCA increases PI3K activity in canalicular and sinusoidal membrane vesicles [ 16 ] . The activation of PI3K in that report was also associated with recruitment of sister of P-glycoprotein (the bile acid export pump) and other multidrug resistance proteins to the canalicular membrane [ 16 ] . Extended treatment of McNtcp.
ATP-dependent transporters on the canalicular membranes of hepatocytes mediate the secretion of bile acids into bile [ 9 ] .
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