Words similar to camp-stimulated
Example sentences for: camp-stimulated
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There is also evidence suggesting that intrarenal EP2 and EP4 receptor activates cAMP-stimulated salt and water transport along the nephron [ 15 16 17 18 ] . Although the localization of EP1, EP3 and EP4 has been determined in human kidney by in situ hybridization, segmental distribution of cAMP-coupled EP2 receptor along the nephron was not detected by this method [ 19 ] . To more clearly define the physiologic role of this cAMP coupled EP receptor, we cloned the rabbit EP 2 receptor, characterized its pharmacology and signaling.
Chloride channels or chloride ions are known to influence cAMP-stimulated steroidogenesis by adrenal cells [ 29 ] , human chorionic gonadotropin (hCG)-stimulated steroidogenesis by amphibian follicle-enclosed oocytes [ 56 ] , as well as LH-stimulated steroidogenesis in rat Leydig cells [ 29 ] , MA-10 cells [ 59 ] , and chicken GC [ 35 ] . In mammalian cells, removal of extracellular chloride stimulates basal and protein kinase A (PKA)-dependent steroid hormone production by increasing the expression of StAR and potentiating the effects of submaximal concentrations of cAMP [ 29 59 ] . The proposed mechanism of action involves chloride efflux, depolarization of the mitochondrial and plasma membranes, and alterations to protein synthesis and cholesterol transport [ 29 59 ] .
We found that none of the USF isoforms affected basal transcription from the RIIβ promoter (not shown) whereas both splice variants of USF2 (a and b) reduced cAMP-stimulated levels of reporter expression to 25%.
For USF1, we observed that a new immunoreactive protein of about 31 kDa was formed only in nuclear extracts from cAMP-stimulated Sertoli cells (Fig.
StAR plays a key role in the initial steps of steroidogenesis, because it is required for transport of cholesterol to the inner mitochondrial membrane where CYP11A1 resides and the first reaction in progesterone synthesis occurs [ 45 ] . cAMP is a well known second messenger in FSH- and LH-stimulated progesterone synthesis, and a key effect of the cAMP-dependent protein kinase in GC is transcriptional control of StAR [ 46 47 ] . Estradiol is recognized as a biological amplifier of basal, FSH- and cAMP-stimulated progesterone production in pig GC, with significant synergistic effects distal to the generation of cAMP at one or more steps in cholesterol transport and metabolism [ 48 ] . Our experimental results are thus consistent with 4-AP inhibition of GC progesterone output via drug effects on multiple interacting sites in the steroidogenic pathway.
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