Words similar to bxpc-

Example sentences for: bxpc-

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Linking of the TGFβ-R pathway to the Ras/MAPK pathway is dependent on a functional SMAD4 gene product, because TGFβ 1 induced gene expression and activation of Ras and ERK1/2 is attenuated by the TGFβ-RII blocking antibody only in SMAD4 wild type cells, whereas in the SMAD4 deleted BxPC-3 cells, no such influence was observable.
Preincubation with a TGFβ-RII blocking antibody attenuated the TGFβ 1 induced pattern, contrary to SMAD 4 deleted BxPC-3 cells.
This TGFβ 1 -induced expression profile was not affected by preincubation of SMAD4 deleted BxPC-3 cells with a TGFβ 1 -RII blocking antibody, which was able to completely block TGFβ 1 -induced SMAD2/3 phosphorylation, thus demonstrating the independence of the TGFβ 1 -signaling from the known SMAD pathway in BxPC-3 cells.
Preincubation of the cells with the MEK1 inhibitor PD98059 curbed the TGFβ 1 -induced regulation of these genes as well, indicating the involvement of the MAP kinase pathway in TGFβ 1 signaling in BxPC-3 cells.
Again, stimulation of TGFβ 1 sensitive cells BxPC-3, LoVo [ 68 ] , SW48 [ 68 ] , Keratinocytes, HeLa and DLD1 [ 69 ] , results in an enhanced cytoskeletal immobilization and tyrosine phosphorylation of cellular proteins in response to stimulation with mature TGFβ 1 (additional file 5).