Words similar to bxpc-
Example sentences for: bxpc-
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This TGFβ 1 -induced expression profile was not affected by preincubation of SMAD4 deleted BxPC-3 cells with a TGFβ 1 -RII blocking antibody, which was able to completely block TGFβ 1 -induced SMAD2/3 phosphorylation, thus demonstrating the independence of the TGFβ 1 -signaling from the known SMAD pathway in BxPC-3 cells.
Preincubation of the cells with the MEK1 inhibitor PD98059 curbed the TGFβ 1 -induced regulation of these genes as well, indicating the involvement of the MAP kinase pathway in TGFβ 1 signaling in BxPC-3 cells.
BxPC-3 cells were stimulated with 10 nM of mature TGFβ 1 for 6 hours.
In order to test whether TGFβ 1 signaling via α V β 6 is specific for SMAD4 deleted BxPC-3 cells or if this is a general phenomenon, we investigated signaling in TGFβ 1 -sensitive carcinoma cell lines HeLa, MCF-7 and MDA-MB-231.
Again, stimulation of TGFβ 1 sensitive cells BxPC-3, LoVo [ 68 ] , SW48 [ 68 ] , Keratinocytes, HeLa and DLD1 [ 69 ] , results in an enhanced cytoskeletal immobilization and tyrosine phosphorylation of cellular proteins in response to stimulation with mature TGFβ 1 (additional file 5).
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