Words similar to bxpc-

Example sentences for: bxpc-

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TGFβ 1 stimulation of these cells acvtivated p21Ras and MAPK ERK1/2, upregulated c-fos, c-jun/AP1, p21/WAF1 and p27 expression, and resulted a decrease of PCNA, similar to its actions in BxPC-3 cells.
In the cell line BxPC-3, lacking the SMAD4 gene product, the SMAD4-independent pathway can explain the TGFβ 1 sensitivity via α V β 6 integrin, the cytoskeleton and the Ras/MAP kinase pathway, resulting in an upregulation of the cell cycle inhibitiors p21/WAF1 and p27, which in turn results in the TGFβ 1 -induced growth inhibition (additional file 10).
In order to generalize the integrin mediated TGFβ 1 -pathway identified in the SMAD4 deleted pancreatic tumor cell line BxPC-3, we investigated TGFβ 1 signaling in the cervical carcinoma cell line HeLa and the mammary carcinoma cell lines MCF-7 and MDA-MB-231, harboring a wildtype SMAD4-gene.
Linking of the TGFβ-R pathway to the Ras/MAPK pathway is dependent on a functional SMAD4 gene product, because TGFβ 1 induced gene expression and activation of Ras and ERK1/2 is attenuated by the TGFβ-RII blocking antibody only in SMAD4 wild type cells, whereas in the SMAD4 deleted BxPC-3 cells, no such influence was observable.
Preincubation of the cells with the MEK1 inhibitor PD98059 curbed the TGFβ 1 -induced regulation of these genes as well, indicating the involvement of the MAP kinase pathway in TGFβ 1 signaling in BxPC-3 cells.