Words similar to bxpc-

Example sentences for: bxpc-

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BxPC-3 cells were stimulated with 10 nM of mature TGFβ 1 for 6 hours.
In the cell line BxPC-3, lacking the SMAD4 gene product, the SMAD4-independent pathway can explain the TGFβ 1 sensitivity via α V β 6 integrin, the cytoskeleton and the Ras/MAP kinase pathway, resulting in an upregulation of the cell cycle inhibitiors p21/WAF1 and p27, which in turn results in the TGFβ 1 -induced growth inhibition (additional file 10).
Again, stimulation of TGFβ 1 sensitive cells BxPC-3, LoVo [ 68 ] , SW48 [ 68 ] , Keratinocytes, HeLa and DLD1 [ 69 ] , results in an enhanced cytoskeletal immobilization and tyrosine phosphorylation of cellular proteins in response to stimulation with mature TGFβ 1 (additional file 5).
This TGFβ 1 -induced expression profile was not affected by preincubation of SMAD4 deleted BxPC-3 cells with a TGFβ 1 -RII blocking antibody, which was able to completely block TGFβ 1 -induced SMAD2/3 phosphorylation, thus demonstrating the independence of the TGFβ 1 -signaling from the known SMAD pathway in BxPC-3 cells.
We also demonstrated the SMAD4 deficiency of the BxPC-3 cells used (Figure 6C).