Words similar to bxpc-

Example sentences for: bxpc-

How can you use “bxpc-” in a sentence? Here are some example sentences to help you improve your vocabulary:

In order to test whether TGFβ 1 signaling via α V β 6 is specific for SMAD4 deleted BxPC-3 cells or if this is a general phenomenon, we investigated signaling in TGFβ 1 -sensitive carcinoma cell lines HeLa, MCF-7 and MDA-MB-231.
BxPC-3 cells were stimulated with 10 nM of mature TGFβ 1 for 6 hours.
Linking of the TGFβ-R pathway to the Ras/MAPK pathway is dependent on a functional SMAD4 gene product, because TGFβ 1 induced gene expression and activation of Ras and ERK1/2 is attenuated by the TGFβ-RII blocking antibody only in SMAD4 wild type cells, whereas in the SMAD4 deleted BxPC-3 cells, no such influence was observable.
Preincubation with a TGFβ-RII blocking antibody attenuated the TGFβ 1 induced pattern, contrary to SMAD 4 deleted BxPC-3 cells.
In the cell line BxPC-3, lacking the SMAD4 gene product, the SMAD4-independent pathway can explain the TGFβ 1 sensitivity via α V β 6 integrin, the cytoskeleton and the Ras/MAP kinase pathway, resulting in an upregulation of the cell cycle inhibitiors p21/WAF1 and p27, which in turn results in the TGFβ 1 -induced growth inhibition (additional file 10).