Words similar to bxpc-

Example sentences for: bxpc-

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We also demonstrated the SMAD4 deficiency of the BxPC-3 cells used (Figure 6C).
BxPC-3 cells were stimulated with 10 nM of mature TGFβ 1 for 6 hours.
Preincubation with a TGFβ-RII blocking antibody attenuated the TGFβ 1 induced pattern, contrary to SMAD 4 deleted BxPC-3 cells.
Linking of the TGFβ-R pathway to the Ras/MAPK pathway is dependent on a functional SMAD4 gene product, because TGFβ 1 induced gene expression and activation of Ras and ERK1/2 is attenuated by the TGFβ-RII blocking antibody only in SMAD4 wild type cells, whereas in the SMAD4 deleted BxPC-3 cells, no such influence was observable.
In order to generalize the integrin mediated TGFβ 1 -pathway identified in the SMAD4 deleted pancreatic tumor cell line BxPC-3, we investigated TGFβ 1 signaling in the cervical carcinoma cell line HeLa and the mammary carcinoma cell lines MCF-7 and MDA-MB-231, harboring a wildtype SMAD4-gene.