Words similar to butaprost
Example sentences for: butaprost
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Incubation of EP 2 -transfected COS1 cells with butaprost free acid produced a concentration-dependent increase in cAMP accumulation with an EC 50 of 480 nM (Fig.
The expression of EP2 receptor mRNA in medullary collecting duct is distinct from functional studies in the cortical collecting duct where butaprost had no functional effect [ 17 18 ] . These data suggest a possible unique role for the EP2 receptor in the medullary collecting duct as opposed to cortical collecting duct.
Cells transfected with the vector alone demonstrated no significant increase in cAMP in response to butaprost free acid.
2 , PGF 2α , iloprost, misoprostol and sulprostone suggest it is not an EP 1 , EP 3 or IP receptor [ 2 3 ] . As demonstrated for the EP 2 receptor in other species [ 6 20 21 ] , butaprost free acid and AH 13205, two synthetic PG agonists with selectivity for the EP 2 subtype, efficiently and dose dependently compete for [ 3H] PGE 2 binding to this newly cloned rabbit receptor.
Prostaglandin E 2 is a major cyclooxygenase metabolite of arachidonic acid which exerts diverse effects on vascular smooth muscle tone and epithelial solute transport via G-protein coupled receptors [ 1 2 ] . At least four distinct G-protein coupled PGE 2 receptors have been cloned: the EP 1 , EP 2 , EP 3 , and EP 4 [ 1 ] . Pharmacological studies suggest PGE 2 relaxes vascular smooth muscle through two of these receptors, the EP 2 and EP 4 receptors, which couple to cyclic-AMP generation [ 3 ] . In contrast, PGE 2 constricts other vascular smooth muscle through EP 3 receptors which inhibit cAMP generation via G i or EP 1 receptors which increase Ca 2+mobilization [ 3 ] . Although both EP 2 and EP 4 receptors relax smooth muscle, EP 2 receptors are uniquely sensitive to the agonists butaprost and AH13205 [ 3 4 ] . Previous studies have shown that PGE 2 increases the cAMP concentration in many tissues including kidney, intestine and uterus, but the relative contribution of EP 2 versus EP 4 receptors to these effects is incompletely defined [ 5 6 ] . Recent studies in mice with targeted disruption of these receptors have suggested an important role for EP2 receptor in regulating systemic hemodynamics.
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