Words similar to butaprost
Example sentences for: butaprost
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In summary, we have cloned and expressed a butaprost sensitive rabbit PGE2 receptor that stimulates cAMP formation and is present in many rabbit tissues.
Furthermore, the EP 2 selective agonists butaprost free acid and AH13205 competed for [ 3H]PGE 2 binding with K i values of 3-7 μM and 3-4 μM, respectively, suggesting this receptor is the rabbit EP 2 receptor [ 20 21 ] .
Prostaglandin E 2 is a major cyclooxygenase metabolite of arachidonic acid which exerts diverse effects on vascular smooth muscle tone and epithelial solute transport via G-protein coupled receptors [ 1 2 ] . At least four distinct G-protein coupled PGE 2 receptors have been cloned: the EP 1 , EP 2 , EP 3 , and EP 4 [ 1 ] . Pharmacological studies suggest PGE 2 relaxes vascular smooth muscle through two of these receptors, the EP 2 and EP 4 receptors, which couple to cyclic-AMP generation [ 3 ] . In contrast, PGE 2 constricts other vascular smooth muscle through EP 3 receptors which inhibit cAMP generation via G i or EP 1 receptors which increase Ca 2+mobilization [ 3 ] . Although both EP 2 and EP 4 receptors relax smooth muscle, EP 2 receptors are uniquely sensitive to the agonists butaprost and AH13205 [ 3 4 ] . Previous studies have shown that PGE 2 increases the cAMP concentration in many tissues including kidney, intestine and uterus, but the relative contribution of EP 2 versus EP 4 receptors to these effects is incompletely defined [ 5 6 ] . Recent studies in mice with targeted disruption of these receptors have suggested an important role for EP2 receptor in regulating systemic hemodynamics.
Finally, the EP 2 selective agonist butaprost free acid dose-dependently stimulated cAMP generation in COS-1 cells transfected with the rabbit EP 2 receptor.
Following this medium containing varying amounts of butaprost free acid was added to each well for 5 minutes.
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