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Example sentences for: butait
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The purified ButaIT was reduced and carboxymethylated by incubating in 6 M guanidine hydrochloride, 0.1 M Tris-HCl (pH 8.3), 1 mM EDTA and 20 mM dithiothreitol for 1 hr at 37°C.
Chemical libraries can be screened for the ability to displace ButaIT leading to the discovery of better pesticides.
Considering the high degree of sequence similarity, it is presumed that ButaIT will have a similar 3-D structure to that of other short toxins.
A structure model of ButaIT, generated from the Swiss-model protein modeling server based on the structural coordinates of chlorotoxin [ 38 ] and insectotoxin I5A [ 22 ] showed that ButaIT adopts a typical core structure of scorpion toxins primarily composed of one α-helix and three β-strands with four disulfide bridges, a feature similar to other toxins of similar size that act on K +and Cl -channels [ 17 31 34 38 ] . It is also evident from the data that disulfide bridge formation in ButaIT likely follows a common motif, with covalent links between cysl6-cys32, cys5-cys27, cys20-cys34 and an additional disulfide bridge between cys2 and cys 19 which cross-links the N-terminal strand of the β-sheet to the α-helix.
When expressed in baculovirus system as a biopesticide scorpion toxins offer the advantage of faster kill without chemical insecticides [ 13 ] . Although the safety of recombinant baculoviruses is less of a concern ButaIT offers an extra level of safety as a recombinant biopesticide due to its specificity to tobacco budworm ion channels.
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