Words similar to bulky
Example sentences for: bulky
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These include 7 hydrophobic residues, two sets of symmetrically positioned small (mostly glycine) and polar (mostly aspartate) residues preceding strands 3 and 6, respectively, and at least three other small residues, two polar residues and two bulky residues (Fig.
The bulky twin-towered cathedral, originally Romanesque, was redesigned in the 17th century.
predicted that Phe158 and Ile 164 form hydrophobic interactions with bulky substituents on the substrate, suggesting that the loss of these residues would only affect binding of substrates with large aromatic substituents [ 37 ] . In the modeling studies on CcrA [ 42 ] , Asn233 was predicted to interact with the β-lactam carbonyl on substrate, and mutagenesis studies have supported this prediction [ 43 ] . Although Asn233 is sequence conserved in L1 [ 35 ] , it is located 14Å away from the modeled position of the β-lactam carbonyl and was predicted not to play a role in substrate binding to L1 [ 37 ] . On the other hand, the substrate-binding model predicted that Tyr228 was in position to offer a hydrogen bond to the β-lactam carbonyl and participate in an oxyanion hole that was proposed to form as the substrate was hydrolyzed [ 37 ] . By using the crystal structure and modeling studies on L1, Ullah et al.
The most notable signature shared by the RDRPs and the YRH proteins is the DbDGD (b is a bulky residue) motif located between strands 19 and 20 (Fig.
These include a doublet comprised of a small and a polar residues preceding each of strands 3 and 6, a small residue after strand 2 (proline in the DDRP β' subunit and RDRP), bulky and polar residues in strand 3, a small residue immediately downstream of strand 5, a bulky residue in the loop between strands 5 and 6, and two hydrophobic residues in strand 6 (Fig.
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