Words similar to bulky

Example sentences for: bulky

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In Ec-MoeB, β sheet 5 (residues 149-155 of Ec-MoeB, Figure 3) forms part of the pocket which accepts the C-terminal portion of MoaD, of which the terminal glycine is subsequently adenylated [ 7 ] . Ec-MoeB I155, located at the C-terminal end of this beta loop, is substituted in MoeBR proteins by Y and in MoeZ proteins by F or Y. These bulky substitutions may restrict access of the C-terminus of MoeD-like proteins and may indicate that a different type of substrate is adenylated by MoeBR and MoeZ.
The sixth position after the conserved basic residue is invariably occupied by a bulky residue that is either arginine (in AlkB) or phenylalanine or tryptophan in all other members of this fold [ 8, 9, 10] (Figure 1).
Thus, large amino acid residues in the CLF of a PKS that makes a 16-carbon chain were replaced by less bulky residues found in one that builds a 20-carbon chain, and the chain length of the product increased as expected.
These include 7 hydrophobic residues, two sets of symmetrically positioned small (mostly glycine) and polar (mostly aspartate) residues preceding strands 3 and 6, respectively, and at least three other small residues, two polar residues and two bulky residues (Fig.
By contrast, ATP would likely not depend on the accessibility of the same hydrophobic cavity and is therefore probably not affected by the incorporation of a bulky methionine side chain [25].