Words similar to bulky
Example sentences for: bulky
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These include 7 hydrophobic residues, two sets of symmetrically positioned small (mostly glycine) and polar (mostly aspartate) residues preceding strands 3 and 6, respectively, and at least three other small residues, two polar residues and two bulky residues (Fig.
In Ec-MoeB, β sheet 5 (residues 149-155 of Ec-MoeB, Figure 3) forms part of the pocket which accepts the C-terminal portion of MoaD, of which the terminal glycine is subsequently adenylated [ 7 ] . Ec-MoeB I155, located at the C-terminal end of this beta loop, is substituted in MoeBR proteins by Y and in MoeZ proteins by F or Y. These bulky substitutions may restrict access of the C-terminus of MoeD-like proteins and may indicate that a different type of substrate is adenylated by MoeBR and MoeZ.
These include a doublet comprised of a small and a polar residues preceding each of strands 3 and 6, a small residue after strand 2 (proline in the DDRP β' subunit and RDRP), bulky and polar residues in strand 3, a small residue immediately downstream of strand 5, a bulky residue in the loop between strands 5 and 6, and two hydrophobic residues in strand 6 (Fig.
Methionine and Tryptophan are fairly bulky; perhaps, the good space filling is the cause for rigidity.
predicted that Phe158 and Ile 164 form hydrophobic interactions with bulky substituents on the substrate, suggesting that the loss of these residues would only affect binding of substrates with large aromatic substituents [ 37 ] . In the modeling studies on CcrA [ 42 ] , Asn233 was predicted to interact with the β-lactam carbonyl on substrate, and mutagenesis studies have supported this prediction [ 43 ] . Although Asn233 is sequence conserved in L1 [ 35 ] , it is located 14Å away from the modeled position of the β-lactam carbonyl and was predicted not to play a role in substrate binding to L1 [ 37 ] . On the other hand, the substrate-binding model predicted that Tyr228 was in position to offer a hydrogen bond to the β-lactam carbonyl and participate in an oxyanion hole that was proposed to form as the substrate was hydrolyzed [ 37 ] . By using the crystal structure and modeling studies on L1, Ullah et al.
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