Example sentences for: btb

How can you use “btb” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Truncation of the BTB domains demonstrated that they were not required for interaction with TOP1.

  • The BTB domain is a highly conserved 120 amino acid, hydrophobic-rich, protein-protein interaction domain that mediates homodimerization and heterodimerization of a large number of proteins with diverse functions [ 9 ] . The three dimensional structure of one BTB domain [ 33 ] has been characterized through structure-function studies [ 34 ] . Proteins containing BTB domains are currently categorized into three groups [ 35 ] : 1) DNA-binding proteins often containing zinc fingers in the C-terminal region, 2) actin binding proteins that contain a kelch repeat of ~50 residues that terminate in a pair of glycine residues [ 36 ] and 3) proteins that have neither an actin-binding domain nor a DNA-binding domain.

  • • Less than the C-terminal half of each BTBD protein lacking the BTB domain is sufficient for binding to TOP1.

  • To determine the localization of BTBD2 in cells, we transiently transfected HeLa cells with expression plasmids encoding either myc-tagged full length BTBD2 (m-BTBD2F) or a truncated BTBD2 having the N-terminal half of the BTB domain removed (m-BTBD2T).

  • aa, amino acid; BTB: Broad-Complex, Tramtrack and Bric-a-brac; GST, glutathione-S-transferase; NLS, nuclear localization signal; ORF, open reading frame; RT-PCR, reverse transcription - polymerase chain reaction; TOP1, DNA topoisomerase I.


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