Example sentences for: bridges

How can you use “bridges” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • While most infrastructure spending takes place at the state, local, or private-sector level, the federal government also invests in infrastructure such as highways, bridges, and air traffic control.

  • They built towns, industries, roads, and bridges, developed agriculture, and bequeathed the Latin language, of which Portuguese is a direct descendant.

  • Robert Stein testified that he put the eight separate pieces of Bridges' body together in the alley and then pronounced Bridges dead.”

  • They were part of the Scarborough Bluffs peninsula until storms and floods in the mid-19th century broke them up into islands, joined today by bridges.

  • Studies in budding yeast identified SCF Cdc4p, an E3 ubiquitin ligase complex that mediates the ubiquitylation of the CDK inhibitor Sic1p [ 3 4 ] . SCF Cdc4pconsists of at least four proteins: the cullin Cdc53p, the RING domain protein Hrt1p/Rbx1p/Roc1p, the adapter protein Skp1p, and Cdc4p (reviewed in [ 1 ] ). Cdc4p contains two sequence motifs, which are conserved in a wide variety of so-called F-box proteins: C-terminal WD-repeats that are involved in binding the substrate Sic1p in a phosphorylation-dependent manner, and a central F-box [ 5 ] that interacts with Skp1p [ 6 7 ] . Cdc53p in turn binds to Skp1p and Hrt1p/Rbx1p/Roc1p, which bridges Cdc53p with the ubiquitin-conjugating enzyme Cdc34p/Ubc3p [ 6 8 9 10 11 12 ] . In vitro reconstitution demonstrated that SCF Cdc4p, Cdc34p, E1, ubiquitin, and ATP are sufficient to mediate Sic1p polyubiquitylation [ 6 7 ] .


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