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Example sentences for: brct

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The highly acidic carboxy-terminal (BRCT) region of BRCA1 has been suggested to play a role in transactivation [ 11 ] . BRCT interacts with BRCA2, Rad51, other tumor suppressing elements, as well as numerous transcription factors, such as RNA helicase A and STAT1 [ 15 16 ] . Recently, it has been discovered that truncation of this region resulted in suppression of apoptosis following pro-apoptotic stimuli [ 17 ] . Further, these studies also suggested that the BRCT region facilitates apoptotic functions within the caspase pathway.
Previous studies have shown that truncation of the highly acidic carboxy-region BRCT resulted in resistance to caspase induced apoptosis [ 17 ] . Further, this failure of apoptosis was traced specifically to caspase 8 and the Fas/FasL pathway.