Words similar to blebbing
Example sentences for: blebbing
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In conclusion, U73343 blocks the MTX-induced cell death cascade in BAECs and converts the normal blebbing profile seen with this toxin into zeiosis, a form of dynamic membrane blebbing commonly associated with apoptosis and characterized by bleb extension and retraction.
Control experiments in which Ca 2+was removed and added back to BAECs in the absence of MTX showed that these responses were dependent on the presence of MTX, i.e., no dye uptake or blebbing was detected in the absence of MTX (Fig 7).
Although the cellular mechanisms remain poorly defined, it is now clear that zeiosis is associated with apoptotic cell death (for review [ 24 30 ] ). In static images, the morphological changes associated with apoptosis appear as membrane blebs covering the surface of the cells [ 31 32 33 ] . However, time-lapse images reveal that blebs protrude and retract in a dynamic fashion, a hallmark of zeiosis [ 22 23 ] . Dynamic membrane blebbing appears to involve a dramatic change in the cytoskeleton and may be induced by a caspase-3-mediated cleavage of ROCK-I, a Rho-activated serine/threonine kinase known to stimulate actinomycin-based contractions [ 31 32 33 ] . A similar profile can be seen in the videos of MTX-induced cell death in the presence of U73343 ( Files 2 and 3 ). The cells first lose adhesion to the coverslip, retract and roundup.
As seen in Fig 5, and in each of these videos, MTX-induced blebbing results in an enormous increase in membrane surface area which may represent stretching of the membrane or an evagination of existing caveolar structures associated with the plasmalemma of endothelial cells.
MTX causes biphasic membrane blebbing
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