Example sentences for: bis-phosphate

How can you use “bis-phosphate” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The gene product of PTEN ( phosphatase and tensin homolog deleted from chromosome 10) is a lipid phosphatase that reverses the activities of phosphatidylinositol 3-kinase (PI3K) by dephosphorylating the D3 position of its lipid products, phosphatidylinositol-3, 4 bis-phosphate (PtdIns(3,4)P2), phosphatidylinositol-3,5 bis-phosphate (PtdIns(3,5)P2), and 3,4,5-tri-phosphate (PtdIns(3,4,5)P3) [ 2, 3], the elevated levels of which are linked to the transforming ability of PI3K [reviewed in ref.

  • In addition, other recent studies have shown that the membrane phospholipid phosohatidylinositol-4,5-bis-phosphate (PIP 2 ) reduces sensitivity of K ATP to ATP, and therefore, activates K ATP [ 32 33 34 ] . To our knowledge, this is the first report of regulation of K ATP activity by phorbol ester in rat β-cells.


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