Words similar to bipartite
Example sentences for: bipartite
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Both clusters of positively charged amino acids are required and can function as a classic bipartite NLS when placed within the right distance (Fig 7).
A RING finger sandwiched between a bipartite NLS could provide additional regulatory mechanisms for nuclear import.
In a typical bipartite NLS, the distance between the two clusters of positively charged amino acids is usually around 10 amino acids.
In some cases, including P. falciparum and HeLa cells, nuclear staining appeared more intense than cytoplasmic staining [ 2 9 ] . Based on studies with heterologously expressed human PP5-GFP fusion proteins, it has been proposed that nuclear localization requires a stretch of sequence in the C terminus [ 31 ] . However, other sequences or signals are also likely to contribute to nuclear localization of PP5 and its homologs, since rat and mouse PP5, which are identical to human PP5 in this region do not appear to be nuclear in all cell types [ 32 33 ] . In addition P. falciparum PP5 is primarily nuclear [ 9 ] , although it is not well conserved in the relevant C-terminal region but contains a potential bipartite nuclear localization signal not found in other PP5 sequences reported thus far.
This sequence is the likely nuclear localization signal (NLS) for these proteins [ 15 ] , similar to the bipartite NLS found in nucleoplasmin [ 36 ] . The one exception is the Langerhans cell protein-1 (LCP1)/KIAA0737 pair, which lacks the second basic residue of the motif.