Example sentences for: bhlh
How can you use “bhlh” in a sentence? Here are some example sentences to help you improve your vocabulary:
A specific complex that formed a Dnase I footprint (-306 to -265) in the cAMP-responsive region of the RIIβ promoter in granulosa cells [ 18 ] , covers a consensus E-box (CACGTG) known to bind helix-loop-helix (bHLH) transcription factors.
Unlike several DNA-binding domains conserved throughout eukaryotes, such as the homeodomain, the bHLH, bZip, C2H2 zinc finger and the RFX domain, APSES domains are restricted to fungi [ 27, 28].
ID2 was recently shown also to be a target of activated β-catenin in colon carcinoma cells [ 13 ] . It is a general inhibitor of the bHLH proteins such as MyoD and E12/E47 [ 14 ] and can interact with the tumor suppressor RB1 [ 15 ] . MSX1 expression can revert differentiated myotubes into an undifferentiated state [ 16 ] . REST/NRSF is known to block neural differentiation by binding to and inhibiting the expression of neuronal genes [ 17 18 ] . To what extent these genes are controlled by Wnt signaling in intact animals or in other cell types is not clear yet, but we do note that MSX mutants have phenotypes similar to LEF/TCF mutants [ 19 20 ] .
It has been shown that the differentiation of pillar cells depends on activation of Fgfr3 [ 26 ] by FGF's, probably Fgf8, a factor produced by developing and mature inner hair cells [ 18 27 ] . The formation of supporting cells also appears to depend on the proper expression of various bHLH factors such as Hes 1 and 5 which appear to be regulated by the Notch signaling pathway [ 17 28 29 ] . It is possible that the apparent inability of fibers to extend along outer hair cells is related to the lack of differentiation of supporting cells in the absence of mature hair cells.
Cell processes that EF-hand proteins may be involved in are suggested by domains found in transcription or translation proteins including elongation factors and the bHLH domain found in transcription factors.
Loading...