Example sentences for: bhlh
How can you use “bhlh” in a sentence? Here are some example sentences to help you improve your vocabulary:
In mammals, the positive elements are two basic helix-loop-helix (bHLH) PAS-domain-containing transcription factors, CLOCK and BMAL1, that form heterodimers that can drive the transcription of three period ( per ) genes per1-3 and two cryptochromes ( cry1,2 ). PER1,2 and CRY1,2 proteins suppress CLOCK:BMAL1-mediated transcription thereby forming the negative elements in the feedback loop.
Cell processes that EF-hand proteins may be involved in are suggested by domains found in transcription or translation proteins including elongation factors and the bHLH domain found in transcription factors.
ID2 was recently shown also to be a target of activated β-catenin in colon carcinoma cells [ 13 ] . It is a general inhibitor of the bHLH proteins such as MyoD and E12/E47 [ 14 ] and can interact with the tumor suppressor RB1 [ 15 ] . MSX1 expression can revert differentiated myotubes into an undifferentiated state [ 16 ] . REST/NRSF is known to block neural differentiation by binding to and inhibiting the expression of neuronal genes [ 17 18 ] . To what extent these genes are controlled by Wnt signaling in intact animals or in other cell types is not clear yet, but we do note that MSX mutants have phenotypes similar to LEF/TCF mutants [ 19 20 ] .
The promoters of a subset of genes in the stress cDNA collection are enriched in G-box and TGA motifs, suggesting that they may be regulated by these bZIP and bHLH transcription factors.
Unlike several DNA-binding domains conserved throughout eukaryotes, such as the homeodomain, the bHLH, bZip, C2H2 zinc finger and the RFX domain, APSES domains are restricted to fungi [ 27, 28].
Loading...