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Example sentences for: bfgf

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Mediators known to activate ECs include inflammatory cytokines, growth factors such as VEGF/VPF and basic fibroblast growth factor (bFGF), extracellular matrix (ECM) proteins such as collagen and fibronectin, and proteases such as MMPs [ 1 2 ] . In vitro and in vivo assays indicate that VEGF signaling promotes increased permeability, cell migration, proliferation, and differentiation, functioning through two EC-specific tyrosine kinase receptor such as Kinase domain receptor (KDR) [ 1 2 3 ] . In the majority of solid tumors, VEGF is upregulated in response to hypoxia, inducing the expression of pro-angiogenic genes that promote tumor angiogenesis, growth and eventual metastasis [ 3 4 5 ] . The expression of both positive and negative factors must be tightly and specifically regulated in a coordinated manner.
The biologic activity of the endostatin encoded in the adenoviral vector was determined through the bFGF simulated HUVEC proliferation assay.
Western blot analysis revealed that VEGF and PMA, but not bFGF, induced the expression of KDR, Flt-1, and the α 2 integrin subunit at 48 hr (Fig.
However, we do not rule out the possibility that growth factors other than BDNF and bFGF could be released by domoic acid-stimulated neonatal microglia cells and play a role in neuroprotection from excitotoxic injury.
The addition of bFGF, VEGF, or PMA to the monolayers ECs induced cellular elongation over a period of 8 to 24 hr.