Words similar to bed-dvh
Example sentences for: bed-dvh
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In this table, the δ V60 's obtained using the C-DVH's and BED-DVH's for each of the matched-patient pairs is displayed.
Because this analysis was performed with two independent measures of merit of the DVH's - the AUC and the V60, the early results reported herein appear promising for the use of BED-DVH's.
The authors are aware of the recent efforts regarding advanced modeling concepts for evaluating the relationship between physical irradiation and biological damage on normal structures - in particular, BED provides a measure of biological effect at a point at which it is calculated - measuring the absolute biological effect over a volume having a non-uniform dose distribution formally requires the computation of the equivalent uniform dose (EUD) [ 23 ] . However, this caveat does not apply directly to the current task, because the goal of the current investigation is to use the DVH (constructed using either conventional dose or BED) as a relative measure of biological response, not as an absolute measure, and in this context constructing a DVH from BED computations and averaging the DVH's (both C-DVH's and BED-DVH's) over a patient population was felt to be an appropriate methodology.
Because the AUC and V60 are dosimetric endpoints used routinely for the evaluation of radiation treatment plans, this analysis suggests that BED-DVH's for the rectum and bladder correlate better with late toxicity than C-DVH's and should be considered when attempting to minimize late GI and GU toxicity after radiotherapy for prostate cancer.
After construction of the C-DVH's and BED-DVH's, it was clear that the general shape of the two were slightly different, as would be expected by the non-linear transformation in Equation (1) above.