Words similar to basolateral

Example sentences for: basolateral

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They found a decrease in total (apical + basolateral) bile acid uptake compared to normal controls [ 12 ] and hypothesized that bile acid malabsorption in cystic fibrosis was due to a primary mucosal defect although they had not specifically studied apical, Na +-dependent absorption.
Surprisingly, the apical surface appeared to be most sensitive to the presence of bacteria, but this could be explained by the fact that the membrane supporting the basolateral cell surface reduced the amount of surface area available for receptor expression.
Of course, a more widespread perturbation of ion channel regulation in the absence of CFTR is also a possibility, as CFTR has been demonstrated to be a master regulator of such diverse proteins as the Na/K pump [ 41 ] , the basolateral Na/K/2Cl co-transporter [ 42 ] , and the inducible nitric oxide synthase [ 43 ] .
One might expect that polarized intestinal epithelial cells would not react strongly to the presence of bacteria on the apical surface (where bacteria are concentrated in the gut), but that the basolateral surface, which in vivo should encounter bacteria only when epithelial integrity is breached, might be more sensitive.
It is also possible that a very small amount of lipotechoic acid (LTA) is penetrating the confluent monolayer, thus stimulating a response from the basolateral surface.