Words similar to base-pairing
Example sentences for: base-pairing
How can you use “base-pairing” in a sentence? Here are some example sentences to help you improve your vocabulary:
Interestingly, perfect or near-perfect target complementarity is associated with mRNA degradation [ 24 25 26 ] , similar to the effects of siRNA, whereas imperfect base-pairing is associated with regulation by translational inhibition [ 6 27 ] . Recently, siRNAs with imperfect match to target mRNA were observed to function as translational inhibitors [ 28 ] , suggesting that the type of 21-22 nucleotide RNA-mediated regulation may be largely determined by the quality of target complementarity.
It might have been the case that point mutations along an arm would be neutral as long as the status of base-pairing was maintained; this is possible due to the acceptability of G-U base-pairing in RNA.
The rationale for defining 'regions' and 'super-regions' came from our observation that RNA folding algorithms would not necessarily identify characteristic pre-miRNA structures if they were folded within the context of longer RNAs, owing to base-pairing with non-miRNA sequence.
While the majority of these structure models contain standard G:C, A:U, and G:U base-pairings arranged into regular secondary structure helices, there were many novel base-pairing exchanges ( e.g., U:U <-> C:C; A:A <-> G:G; G:U <-> A:C; etc. ) and base pairs that form tertiary or tertiary-like structural elements.
We analyzed conserved regions with mfold 3.1, an RNA-folding algorithm [ 41 ] . As miRNA genes can be located on either strand, and the quality of predicted hairpin structures can vary significantly between the respective strands (depending on the amount of G-U base-pairing), we folded each region as both the forward and the reverse complement of the extracted sequence (436,000 regions × 2 = 872,000 mfolds).
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