Words similar to base-pairing
Example sentences for: base-pairing
How can you use “base-pairing” in a sentence? Here are some example sentences to help you improve your vocabulary:
We analyzed conserved regions with mfold 3.1, an RNA-folding algorithm [ 41 ] . As miRNA genes can be located on either strand, and the quality of predicted hairpin structures can vary significantly between the respective strands (depending on the amount of G-U base-pairing), we folded each region as both the forward and the reverse complement of the extracted sequence (436,000 regions × 2 = 872,000 mfolds).
It might have been the case that point mutations along an arm would be neutral as long as the status of base-pairing was maintained; this is possible due to the acceptability of G-U base-pairing in RNA.
While the majority of these structure models contain standard G:C, A:U, and G:U base-pairings arranged into regular secondary structure helices, there were many novel base-pairing exchanges ( e.g., U:U <-> C:C; A:A <-> G:G; G:U <-> A:C; etc. ) and base pairs that form tertiary or tertiary-like structural elements.
The rationale for defining 'regions' and 'super-regions' came from our observation that RNA folding algorithms would not necessarily identify characteristic pre-miRNA structures if they were folded within the context of longer RNAs, owing to base-pairing with non-miRNA sequence.
Interestingly, perfect or near-perfect target complementarity is associated with mRNA degradation [ 24 25 26 ] , similar to the effects of siRNA, whereas imperfect base-pairing is associated with regulation by translational inhibition [ 6 27 ] . Recently, siRNAs with imperfect match to target mRNA were observed to function as translational inhibitors [ 28 ] , suggesting that the type of 21-22 nucleotide RNA-mediated regulation may be largely determined by the quality of target complementarity.
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