Words similar to autoreactive

Example sentences for: autoreactive

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These non-physiologic RSS are important because of their potential involvement in oncogenic chromosomal translocation and receptor editing, a process that alters the specificity of autoreactive receptors.
In induced models of autoimmunity, the CD28-B7 interaction has been shown to regulate disease susceptibility by rendering autoreactive T cells anergic, or alternatively by upregulating the threshold for autoreactive T-cell activation [ 30 ] . Furthermore, we previously showed that impaired Fas-mediated activation-induced cell death (AICD) of autoreactive T-helper-1 cells may be responsible for the development of PGIA [ 20 ] . Therefore, AICD and/or T-cell anergy, but not the CD4 +CD25 +regulatory T cells, may be responsible for deletion or inactivation of autoreactive T cells in autoimmune arthritis.
Furthermore, expanded clones of CD4 +CD28 -T cells exist in the blood and synovial compartments of such patients [ 5] and these T cells appear to be autoreactive [ 6].
Some of the autoreactive T cells, however, may escape from negative selection and are released into the periphery.
Thus, lack of exposure to a self-antigen in the thymus may lead to the presence of autoreactive T cells and increase the risk of autoimmunity.