Example sentences for: atrip

How can you use “atrip” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Rad26 is a regulatory subunit of the Rad26/Rad3 complex that is required for Rad3 kinase activity [ 18 ] . Following DNA damage, Rad26 undergoes Rad3-dependent phosphorylation [ 17 ] . Rad26 is a 70 kDa protein containing little informative sequence information beyond a predicted coiled-coil region and a basic stretch that resembles a nuclear localization signal [ 13 32 ] . Functionally conserved proteins with very weak sequence similarity have been found in human (ATRIP) [ 35 ] , S. cerevisiae LCD1 (aka DDC2 and PIE1) [ 36 37 38 ] and A. nidulans (UVSD) [ 32 ] .

  • [ 35 ] found that ATRIP Rad26and ATR Rad3also re-localize to a large number of intranuclear foci.

  • In budding yeast, LCD1 Rad26physically interacts with MEC1 Rad3and is phosphorylated by MEC1 Rad3following DNA damage [ 36 37 ] . Likewise, human ATRIP Rad26physically interacts with ATR Rad3and also undergoes DNA damage-dependent phosphorylation by ATR Rad3 [ 35 ] . However, Rad26 is required for Rad3 kinase activity in fission yeast [ 18 ] , but LCD1 Rad26is not required for MEC1 Rad3kinase activity [ 38 ] while ATRIP Rad26is required for normal ATR Rad3expression [ 35 ] . Thus, the role of the Rad26-related proteins can differ among organisms.

  • Unlike ATRIP and LCD1-GFP, Rad26-GFP also localizes to one or two bright spots following DNA damage (Figure 5).


How many words do you know? Try our free vocabulary size test!


Search

Search for example sentences

Loading Loading...
Quantcast