Example sentences for: atr

How can you use “atr” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In budding yeast, LCD1 Rad26physically interacts with MEC1 Rad3and is phosphorylated by MEC1 Rad3following DNA damage [ 36 37 ] . Likewise, human ATRIP Rad26physically interacts with ATR Rad3and also undergoes DNA damage-dependent phosphorylation by ATR Rad3 [ 35 ] . However, Rad26 is required for Rad3 kinase activity in fission yeast [ 18 ] , but LCD1 Rad26is not required for MEC1 Rad3kinase activity [ 38 ] while ATRIP Rad26is required for normal ATR Rad3expression [ 35 ] . Thus, the role of the Rad26-related proteins can differ among organisms.

  • DNA repair activities may take place at these foci since BRCA1 has been shown to co-localize with ATR in damage-induced foci [ 58 ] . Using elegant methods to test for direct association of DNA damage checkpoint proteins at double strand breaks in vivo , other groups have shown that MEC1 Rad3-HA and LCD1 Rad26-GFP localize to sites of DNA damage [ 59 60 ] . However, MEC1 was required for this re-localization of LCD1-GFP in vivo [ 60 ] . Thus, while re-localization of Rad26/Rad3-related complexes to sites of DNA repair may be evolutionarily conserved, the regulation of these complexes is not.

  • ATR file for Figure 7

  • The three types of files provided for each example (ATR, GTR, CDT) must be copied in the same folder before opening the CDT file with Treeview.


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