Words similar to atr
Example sentences for: atr
How can you use “atr” in a sentence? Here are some example sentences to help you improve your vocabulary:
The literature profiles of Figures 6 and 7 (ATR ( Figure 6and Figure 7), GTR ( Figure 6and Figure 7) and CDT files ( Figure 6and Figure 7)) can be read by the well-known open source dendrogram browser Treeview [ 10].
ATR file for Figure 6
In budding yeast, LCD1 Rad26physically interacts with MEC1 Rad3and is phosphorylated by MEC1 Rad3following DNA damage [ 36 37 ] . Likewise, human ATRIP Rad26physically interacts with ATR Rad3and also undergoes DNA damage-dependent phosphorylation by ATR Rad3 [ 35 ] . However, Rad26 is required for Rad3 kinase activity in fission yeast [ 18 ] , but LCD1 Rad26is not required for MEC1 Rad3kinase activity [ 38 ] while ATRIP Rad26is required for normal ATR Rad3expression [ 35 ] . Thus, the role of the Rad26-related proteins can differ among organisms.
DNA repair activities may take place at these foci since BRCA1 has been shown to co-localize with ATR in damage-induced foci [ 58 ] . Using elegant methods to test for direct association of DNA damage checkpoint proteins at double strand breaks in vivo , other groups have shown that MEC1 Rad3-HA and LCD1 Rad26-GFP localize to sites of DNA damage [ 59 60 ] . However, MEC1 was required for this re-localization of LCD1-GFP in vivo [ 60 ] . Thus, while re-localization of Rad26/Rad3-related complexes to sites of DNA repair may be evolutionarily conserved, the regulation of these complexes is not.
A more likely candidate is the Atr protein kinase, a kinase related to DNA-PK [ 44], which can regulate the phosphorylation of serine 37 of p53 in response to DNA damage.
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