Words similar to astrocytes
Example sentences for: astrocytes
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.. ", together with paralytic, neurotoxic, diarrhetic and ciguatera fish poisoning (FDA website: http://vm.cfsan.fda.gov/~dms/haccp-2f.html) [ 14 ] . Recent behavioral toxicity studies in rodents, have confirmed that domoic acid is a very rapid and potent neurotoxin in newborn rats, at doses far lower than in adult animals [ 15 16 17 ] . Even though hippocampal pyramidal neurons and mossy fiber terminals appear to be selectively targeted in vivo by domoic acid in rat [ 18 ] and cynomolgus monkey brain [ 19 ] , recently domoic acid was shown to affect glutamate uptake by astrocytes in vitro and " ...thus produced neurotoxicity.
This antibody recognizes Schwann and ensheathing cells of the olfactory nerve but not astrocytes.
Finally, astrocytes and neurons in the lumbosacral spinal cord contain MIF.
Similarly, inositol 1,4,5-trisphosphate receptors (IP3R) are intracellular calcium release channels involved in diverse signaling pathways and are required for the activation of T lymphocytes [ 33 ] . Tat (also implicated as a neurotoxin) has been shown to release calcium from inositol 1,4, 5-trisphosphate (IP3) receptor-regulated stores in neurons and astrocytes causing premature apoptosis [ 34 ] . Down-regulation of IP3 may therefore contribute to viral latency and maintenance of an anti-apoptotic state in cells.
Cortical astrocytes were harvested from neonatal C57BL/6 mice and infected with a replication-defective retrovirus encoding Tag and neomycin resistance as previously described [ 13 ] . The transferred viruses were SV40-6 [ 5 ] , in which wild type Tag is expressed from the M-MuLV LTR promoter; SV(X)T K1, which is constructed the same as SV40-6 except that the Tag is mutant [ 38 ] and defective for binding the retinoblastoma protein family [ 39 ] ; Linker-tkT, in which the cDNA for Tag is expressed from the herpes simplex 1 tk promoter [ 11 ] . The differentiation and transformation phenotypes of the cell lines utilizing the M-MuLV LTR promoter have been described [ 6 13 ] . The Linker-tkT lines (tkT) were either isolated as clones after G418 selection (as previously described) [ 6 ] or frozen immediately after selection (pooled clones) and clonally selected at a later time.
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