Words similar to arthritogenic
Example sentences for: arthritogenic
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Interestingly, both IFN-γ and TNF-α are prominent in the pathogenesis of autoimmune diseases in general; the former by activation of local auto antigen presentation to appropriate T cells, and the latter by mediation of inflammatory tissue damage [ 68 ] . Apparently TNF-α plays a central role in the chronic release of highly arthritogenic II-1 [ 69 ] , and thus serves as a major factor in the pathogenesis of rheumatoid arthritis (RA) [ 69 ] . Recent studies show that treatment with anti-TNF-α gives significant clinical improvement in RA [ 70 ] . Thus our findings in aged individuals of a prominent CD8 +CD28 -T cell subset with enhanced ability to produce TNF-α, may assume clinical relevance.
As a control, the same number of CD4 +CD25 -T cells, together with arthritogenic spleen cells that were depleted of CD25 +cells, and proteoglycan, were also adoptively transferred into SCID mice.