Words similar to arthritis
Example sentences for: arthritis
How can you use “arthritis” in a sentence? Here are some example sentences to help you improve your vocabulary:
In the patients, the rheumatolgic evaluation included a search for the presence of diagnostic criteria for SLE, RA, AS, psoriatic arthritis, JRA, polymyositis/dermatomyositis, scleroderma/CREST (calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, telangiectasia), and Behcet's syndrome [ 22].
Recent studies [ 20, 32] have demonstrated that the synovial tissue of rheumatoid arthritis patients can develop lymphoid aggregates that have the cellular components of an ectopic germinal center and that can sustain B-cell clonal expansion and diversification.
Of note, TRANCE-mediated activation of osteoclasts has recently been shown [ 19] to play an important role in the damage to bone found in experimental models of inflammatory arthritis.
In order to synchronize the onset of arthritis, lipopolysaccharide was injected intraperitoneally on day 28, excluding the mice that had already showed signs of disease pathology.
Once in the tissue, monocytes undergo the poorly understood process of transformation to macrophages with altered morphology and function [ 19 ] . In arthritis, synovial macrophages might cause joint destruction by differentiating to bone-resorbing osteoclasts [ 20 ] or by releasing cartilage-degrading enzymes and cytokines, such as interleukin-1 and tumor necrosis factor-α [ 8 ] . It has therefore been suggested that therapies for chronic arthritis should be aimed at depleting joint mononuclear cells or controlling the activation of synovial macrophages [ 21 ] . Indeed, elimination of macrophages by clodronate-laden liposomes in rat models of adjuvant [ 22 ] and antigen-induced arthritis [ 23 ] induces amelioration of the arthritis.
Loading...