Words similar to arf
Example sentences for: arf
How can you use “arf” in a sentence? Here are some example sentences to help you improve your vocabulary:
Of these, 15 genes ( MGMT , RASSF1A , APC , RARB , CDH1 , MLH1 , TIMP3 , GSTP1 , DAPK , CDKN2A , p14 ARF , BRCA1 , FHIT , TP73 , and HIC1 ) had previously been shown to be commonly methylated in various solid tumor types [ 4 ] . Six additional genes ( RB1 , NME1 , NME2 , BTG1 , NEDD1 , and APAF1 ) were studied because of their possible involvement in genetic alterations in GCT as indicated by LOH studies [ 8 9 10 ] . The RB1 gene at 13q14.
Again, the villain is precise pronunciation: with the possible exception of Little Orphan Annie's dog Sandy, no mutt barks arf .
The enzyme exhibits a high constitutive activity in vitro, but it too can be activated by ARF (reviewed in [ 7 ] ), and by phorbol esters, in intact cells [ 6 9 ] . Several reports have suggested that PLD2 is mainly localized to the plasma membrane [ 6 10 ] , possibly in lipid rafts and caveolar membrane microdomains [ 11 12 ] . Most studies on the physiological functions of PLDs have focused on the product PA, a second messenger involved in mitosis, cellular morphological changes and vesicular trafficking (reviewed in [ 7 13 ] ). However, the downstream events that occur as a consequence of PLD-generated PA production, and the identity of target proteins that are directly regulated by PA remains to be determined.
The use of diuretics in the management of ARF remains controversial despite several advances in the understanding of the pathogenesis of renal failure and the mechanisms of action of the agents commonly used to manage it.
Moreover, data drawn from animal experiments, where compounds such as uranyl nitrate or glycerol were used to induce ARF, must be interpreted with caution [ 1].
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