Words similar to ar-dependent

Example sentences for: ar-dependent

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Comparison of the expression patterns of genital fibroblasts from 46,XY normal males and 46,XY females with inactivated AR provides a window on the AR-dependent gene-expression programs within the urogenital mesenchyme, which contribute to the development and structural integrity of male and female genitalia.
A critical question raised by these results is whether the observed differences between genital fibroblasts from males and AIS females reflect cell-autonomous effects of androgen exposure during development, or indirect effects of the AR-dependent genital morphogenetic program.
Both MAP kinase and STAT pathways are involved in AR-dependent regulation and in ligand-independent activation of the AR [ 18 ] . Differential expression of aldehyde dehydrogenase 1A1 and alcohol dehydrogenase 1B, enzymes that affect retinoic acid biosynthesis, suggest that other signaling pathways may participate in the AR-initiated programs of external genital differentiation [ 19 20 ] .
The molecular events responsible for AR-dependent male genital morphogenesis are poorly understood.
We hypothesized that the AR-dependent mesenchymal programs underlying male external genitalia development might be illuminated by comparing the transcriptional profile of mesenchyme-derived stromal cells from normal males to those from individuals affected with AIS.