Words similar to ar
Example sentences for: ar
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The increased concentration of ABP present in the testes of TG mice (see Joseph et al . [ 25 ] ) will chronically reduce the concentration of intra-testicular free T available for interaction with androgen receptor (AR) and other molecular targets.
Luciferase reporter plasmids containing specific responsive elements for AR, GR, and PR (GRE-TATA-luciferase) and ER (ERE-TATA-luciferase) have been described elsewhere [ 29 30 ] ; another androgen-responsive reporter contained the fragment -286/+28 of the rat Probasin (PB) promoter, and was obtained from Dr. R. Matusik, Vanderbilt University, TN [ 31 ] . An expression plasmid for wild-type hAR was kindly provided by Dr. C. Chang, University of Rochester, NY.
Cotransfection of a plasmid expressing a constitutively active mutant Stat3, Stat3C, that forms homodimers and translocates to the nucleus without tyrosine phosphorylation, affected AR transcriptional activity in a dose-response manner (Fig.
Some genes expressed in wild-type AR cells could influence androgen signaling.
Activated Stat3 d oes not affect the specificity of AR to bind to other HREs different form ARE.