Example sentences for: apv

How can you use “apv” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Since the above pharmacokinetic studies and others involving pharmacokinetic modeling predictions were conducted over only a short period (generally ≤ 14 days) and in a small number of patients, there remained a need to evaluate low-dose APV/RTV combinations in large populations of HIV-1-infected patients over a therapeutically relevant period.

  • The virological results of this study indicate that over a 24-week treatment period the APV600/RTV regimen was statistically similar to or better than the APV1200 regimen according to the <200 copies/mL endpoint criterion.

  • Target enrollment was 198 in the APV600/RTV arm and 66 in the APV1200 arm.

  • The greater magnitude of virologic suppression in the study population as a whole with the APV600/RTV regimen was expected in view of the results of earlier clinical pharmacokinetic studies showing a >6-fold higher C min level with APV600/RTV BID compared with the APV1200 BID regimen [ 16 ] . Higher C min values achieved with RTV-boosting may be critical in treating antiretroviral-experienced patients, particularly those with HIV isolates having increased IC 50 values.

  • The study was powered to evaluate whether the virologic efficacy (proportion of patients with plasma HIV-1 HIV <200 copies/mL at week 24) in the APV 600/RTV arm was at least as good (non-inferior) as in the APV1200 arm.


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