Words similar to apv
Example sentences for: apv
How can you use “apv” in a sentence? Here are some example sentences to help you improve your vocabulary:
The purpose of ESS40011 was to compare the efficacy, safety, and tolerability of APV 600 mg BID plus RTV 100 mg BID (APV600/RTV) to APV 1200 mg BID (APV1200) over 24 weeks in antiretroviral-naïve or -experienced HIV-infected patients who were receiving other background antiretroviral drugs.
Of note, a significantly greater proportion of patients in the APV600/RTV treatment arm achieved HIV-1 RNA <50 copies/mL at week 24, which was a secondary endpoint.
It is possible that proportionally more treatment-naïve patients may have responded to APV600/RTV due to poorer or more difficult adherence to the APV1200 regimen, but no adherence checks were included in this study to verify this.
The increase in CD4+ cells observed at 24 weeks in the APV600/RTV BID arm was not different from that in the APV1200 arm.
To reduce APV pill burden and possibly improve tolerability of APV treatment, pharmacokinetic research efforts have been directed at combining APV with the PI ritonavir (RTV), which inhibits CYP3A4-mediated hepatic metabolism of APV, thereby enhancing plasma APV exposure [ 13 14 15 ] . The administration of RTV at the clinically sub-therapeutic dosage of 100 mg BID was found to boost APV plasma exposure to such a degree as to permit halving the APV daily pill burden from 16 to 8 capsules/day, in addition to maintaining the minimum plasma APV concentration (C min ) over 24 hours well above the 50% inhibitory concentrations (IC 50 ) of patient-derived HIV-1 isolates [ 15 ] . A pharmacokinetic study in 20 HIV-infected patients, PROF1004, showed that APV at the lower dosage of 600 mg BID combined with RTV 100 mg BID (APV600/RTV) resulted in a geometric mean steady-state APV C min (1.
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